Seroatlas · Human Serome Atlas

TCERG1L

Transcription elongation regulator 1-like protein

Also known as: FLJ38950, TCRGL_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VWI1
Gene: TCERG1L
Ensembl: ENSG00000176769
Chromosome: 10
Canonical length: 586 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable RNA polymerase binding activity and transcription coregulator activity. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

586 residues, UniProt reviewed canonical sequence.

>Q5VWI1|TCERG1L
     1  MQAGARFQRR RRQLQQQQPR RRQPLLWPMD AEPPPPPPWV WMVPGSAGLL RLSAGVVVPP
    61  VLLASAPPPA APLLPGLPGW PAPSEPVLPL LPLPSAPDSA AAAAAHPFPA LHGQWLFGGH
   121  SPSLGLPPSS TVELVPVFPH LCPSALATPI GKSWIDKRIP NCKIFFNNSF ALDSTWIHPE
   181  ESRFFHGHEK PRLLANQVAV SLSRPAPASR PLPTVVLAPQ PIPGGCHNSL KVTSSPAIAI
   241  ATAAAAAMVS VDPENLRGPS PSSVQPRHFL TLAPIKIPLR TSPVSDTRTE RGRVARPPAL
   301  MLRAQKSRDG DKEDKEPPPM LGGGEDSTAR GNRPVASTPV PGSPWCVVWT GDDRVFFFNP
   361  TMHLSVWEKP MDLKDRGDLN RIIEDPPHKR KLEAPATDNS DGSSSEDNRE DQDVKTKRNR
   421  TEGCGSPKPE EAKREDKGTR TPPPQILLPL EERVTHFRDM LLERGVSAFS TWEKELHKIV
   481  FDPRYLLLNS EERKQIFEQF VKTRIKEEYK EKKSKLLLAK EEFKKLLEES KVSPRTTFKE
   541  FAEKYGRDQR FRLVQKRKDQ EHFFNQFILI LKKRDKENRL RLRKMR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TCERG1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 14 nTPM
cerebral cortex: 7.3 nTPM
retina: 5.7 nTPM
hippocampal formation: 2.7 nTPM
ovary: 2.7 nTPM
hypothalamus: 2.4 nTPM

Single-cell type

retinal horizontal cells: 665 nCPM
retinal amacrine cells: 123 nCPM
gonadotrophs: 108 nCPM
cone photoreceptor cells: 87 nCPM
retinal ganglion cells: 85 nCPM
adrenal medulla cells: 75 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 16 nTPM
basal ganglia: 13 nTPM
thalamus: 9.7 nTPM
white matter: 9.7 nTPM
hypothalamus: 9.4 nTPM
medulla oblongata: 8.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.06
gnomAD pLI: 0
gnomAD missense Z: 0.47
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Repeat

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TCERG1L as an antibody target. Whether an autoantibody or antibody against TCERG1L could matter depends on whether native TCERG1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TCERG1L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TCERG1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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