Seroatlas · Human Serome Atlas

TCEANC2

Transcription elongation factor A N-terminal and central domain-containing protein 2

Also known as: C1orf83, FLJ32112, TEAN2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96MN5
Gene: TCEANC2
Ensembl: ENSG00000116205
Chromosome: 1
Canonical length: 208 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

208 residues, UniProt reviewed canonical sequence.

>Q96MN5|TCEANC2
     1  MDKFVIRTPR IQNSPQKKDS GGKVYKQATI ESLKRVVVVE DIKRWKTMLE LPDQTKENLV
    61  EALQELKKKI PSREVLKSTR IGHTVNKMRK HSDSEVASLA REVYTEWKTF TEKHSNRPSI
   121  EVRSDPKTES LRKNAQKLLS EALELKMDHL LVENIERETF HLCSRLINGP YRRTVRALVF
   181  TLKHRAEIRA QVKSGSLPVG TFVQTHKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TCEANC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 7.6 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 7.6 nTPM
midbrain: 6.4 nTPM
testis: 6.2 nTPM
basal ganglia: 4.9 nTPM
hippocampal formation: 4.9 nTPM
amygdala: 4.8 nTPM

Single-cell type

early primary spermatocytes: 59 nCPM
late primary spermatocytes: 47 nCPM
esophageal apical cells: 38 nCPM
late spermatids: 34 nCPM
early spermatids: 34 nCPM
choroid plexus epithelial cells: 32 nCPM

Immune cell

NK-cell: 4.8 nTPM
eosinophil: 4.2 nTPM
intermediate monocyte: 4.1 nTPM
basophil: 3.5 nTPM
myeloid DC: 3.5 nTPM
neutrophil: 3.4 nTPM

Brain region

white matter: 13 nTPM
thalamus: 12 nTPM
amygdala: 12 nTPM
medulla oblongata: 12 nTPM
basal ganglia: 11 nTPM
pons: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.67
gnomAD pLI: 0
gnomAD missense Z: 0.29
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TCEANC2 as an antibody target. Whether an autoantibody or antibody against TCEANC2 could matter depends on whether native TCEANC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TCEANC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TCEANC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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