TCEAL9
Transcription elongation factor A protein-like 9
Also known as: DKFZp313K1940, TCAL9_HUMAN, WBP5, WEX6
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9UHQ7
- Gene
- TCEAL9
- Ensembl
- ENSG00000185222
- Chromosome
- X
- Canonical length
- 104 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Nucleoli
OverviewNCBI Gene
The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. This gene encodes a WW domain binding protein. This gene also encodes a domain with similarity to the transcription elongation factor A, SII-related family. Alternative splicing results in multiple transcript variants encoding a single isoform. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
104 residues, UniProt reviewed canonical sequence.
>Q9UHQ7|TCEAL9
1 MKSCQKMEGK PENESEPKHE EEPKPEEKPE EEEKLEEEAK AKGTFRERLI QSLQEFKEDI
61 HNRHLSNEDM FREVDEIDEI RRVRNKLIVM RWKVNRNHPY PYLMLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TCEAL9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.59
- Highest tissue expression
- 321 nTPM
Expression across tissuesHPA
Tissue
- ovary: 321 nTPM
- placenta: 206 nTPM
- adrenal gland: 196 nTPM
- epididymis: 175 nTPM
- choroid plexus: 155 nTPM
- blood vessel: 136 nTPM
Single-cell type
- cytotrophoblasts: 1,283 nCPM
- migrating cytotrophoblasts: 1,072 nCPM
- syncytiotrophoblasts: 912 nCPM
- epididymal basal cells: 623 nCPM
- megakaryocytes: 563 nCPM
- ovarian stromal cells: 555 nCPM
Immune cell
- plasmacytoid DC: 24 nTPM
- naive CD4 T-cell: 4 nTPM
- naive CD8 T-cell: 3.5 nTPM
- memory B-cell: 2.4 nTPM
- memory CD4 T-cell: 1.9 nTPM
- classical monocyte: 1.6 nTPM
Brain region
- choroid plexus: 70 nTPM
- white matter: 44 nTPM
- medulla oblongata: 35 nTPM
- cerebral cortex: 33 nTPM
- midbrain: 33 nTPM
- pons: 33 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.82
- gnomAD pLI
- 0.12
- DepMap mean gene effect
- -0.01
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TCEAL9 as an antibody target. Whether an autoantibody or antibody against TCEAL9 could matter depends on whether native TCEAL9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TCEAL9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TCEAL9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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