TCEAL8
Transcription elongation factor A protein-like 8
Also known as: MGC45400, TCAL8_HUMAN, WEX3
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q8IYN2
- Gene
- TCEAL8
- Ensembl
- ENSG00000180964
- Chromosome
- X
- Canonical length
- 117 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm
OverviewNCBI Gene
This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family contain TFA domains and may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
117 residues, UniProt reviewed canonical sequence.
>Q8IYN2|TCEAL8
1 MQKSCEENEG KPQNMPKAEE DRPLEDVPQE AEGNPQPSEE GVSQEAEGNP RGGPNQPGQG
61 FKEDTPVRHL DPEEMIRGVD ELERLREEIR RVRNKFVMMH WKQRHSRSRP YPVCFRPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TCEAL8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.65
- Highest tissue expression
- 124 nTPM
Expression across tissuesHPA
Tissue
- epididymis: 124 nTPM
- heart muscle: 87 nTPM
- ovary: 79 nTPM
- thymus: 67 nTPM
- thyroid gland: 67 nTPM
- parathyroid gland: 67 nTPM
Single-cell type
- epididymal principal cells: 360 nCPM
- megakaryocytes: 359 nCPM
- migrating cytotrophoblasts: 274 nCPM
- extravillous trophoblasts: 215 nCPM
- decidual stromal cells: 204 nCPM
- cytotrophoblasts: 203 nCPM
Immune cell
- NK-cell: 121 nTPM
- T-reg: 110 nTPM
- plasmacytoid DC: 102 nTPM
- naive CD4 T-cell: 85 nTPM
- memory CD4 T-cell: 78 nTPM
- MAIT T-cell: 77 nTPM
Brain region
- cerebral cortex: 48 nTPM
- spinal cord: 45 nTPM
- white matter: 44 nTPM
- cerebellum: 43 nTPM
- hypothalamus: 43 nTPM
- medulla oblongata: 42 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.21
- gnomAD pLI
- 0.54
- gnomAD missense Z
- 0.36
- DepMap mean gene effect
- 0.05
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TCEAL8 as an antibody target. Whether an autoantibody or antibody against TCEAL8 could matter depends on whether native TCEAL8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TCEAL8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TCEAL8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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