Seroatlas · Human Serome Atlas

TCEAL7

Transcription elongation factor A protein-like 7

Also known as: MGC23947, TCAL7_HUMAN, WEX5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BRU2
Gene
TCEAL7
Ensembl
ENSG00000182916
Chromosome
X
Canonical length
100 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Involved in negative regulation of DNA-templated transcription and negative regulation of NF-kappaB transcription factor activity. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

100 residues, UniProt reviewed canonical sequence.

>Q9BRU2|TCEAL7
     1  MQKPCKENEG KPKCSVPKRE EKRPYGEFER QQTEGNFRQR LLQSLEEFKE DIDYRHFKDE
    61  EMTREGDEME RCLEEIRGLR KKFRALHSNH RHSRDRPYPI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TCEAL7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
121 nTPM

Expression across tissuesHPA

Tissue

  • hypothalamus: 121 nTPM
  • spinal cord: 118 nTPM
  • cerebral cortex: 99 nTPM
  • midbrain: 96 nTPM
  • cerebellum: 92 nTPM
  • amygdala: 86 nTPM

Single-cell type

  • müller glia: 88 nCPM
  • decidual stromal cells: 79 nCPM
  • other brain neurons: 72 nCPM
  • ovarian stromal cells: 65 nCPM
  • breast myoepithelial cells: 55 nCPM
  • granulosa cells: 51 nCPM

Immune cell

  • NK-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • white matter: 121 nTPM
  • hypothalamus: 103 nTPM
  • pons: 97 nTPM
  • medulla oblongata: 94 nTPM
  • cerebral cortex: 93 nTPM
  • midbrain: 87 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.43
gnomAD pLI
0.48
gnomAD missense Z
0.38
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TCEAL7 as an antibody target. Whether an autoantibody or antibody against TCEAL7 could matter depends on whether native TCEAL7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TCEAL7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TCEAL7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TCEAL7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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