Seroatlas · Human Serome Atlas

TCEAL6

Transcription elongation factor A protein-like 6

Also known as: TCAL6_HUMAN, WEX2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6IPX3
Gene: TCEAL6
Ensembl: ENSG00000204071
Chromosome: X
Canonical length: 200 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

200 residues, UniProt reviewed canonical sequence.

>Q6IPX3|TCEAL6
     1  MEKPYNKNEG NLENEGKPED EVEPDDEGKS DEEEKPDAEG KTECEGKRKA EGEPGDEGQL
    61  EDKGSQEKQG KSEGEGKPQG EGKPASQAKP EGQPRAAEKR PAGDYVPRKA KRKTDRGTDD
   121  SPKDSQEDLQ ERHLSSEEMM RECGDVSRAQ EELRKKQKMG GFHWMQRDVQ DPFAPRGQRG
   181  VRGVRGGGRG QRGLHDIPYL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TCEAL6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 96 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 96 nTPM
cerebral cortex: 82 nTPM
hypothalamus: 81 nTPM
pituitary gland: 68 nTPM
amygdala: 52 nTPM
basal ganglia: 49 nTPM

Single-cell type

sertoli cells: 43 nCPM
granulosa cells: 39 nCPM
other brain neurons: 37 nCPM
gonadotrophs: 31 nCPM
lactotrophs: 27 nCPM
pituicytes/fscs: 25 nCPM

Immune cell

NK-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebral cortex: 81 nTPM
hypothalamus: 71 nTPM
midbrain: 66 nTPM
pons: 53 nTPM
basal ganglia: 53 nTPM
medulla oblongata: 48 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.93
gnomAD pLI: 0.02
gnomAD missense Z: -0.62

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TCEAL6 as an antibody target. Whether an autoantibody or antibody against TCEAL6 could matter depends on whether native TCEAL6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TCEAL6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TCEAL6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...