Seroatlas · Human Serome Atlas

TCEAL5

Transcription elongation factor A protein-like 5

Also known as: TCAL5_HUMAN, WEX4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5H9L2
Gene: TCEAL5
Ensembl: ENSG00000204065
Chromosome: X
Canonical length: 206 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene, which is located on the X chromosome, encodes a protein which contains a BEX (brain expressed X-liked like family) domain. This domain is found in proteins encoded by the TCEAL elongation factor (transcription elongation factor A (SII)-like) gene family also located on the X chromosome. The coding region for this gene is located entirely in the terminal exon. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

206 residues, UniProt reviewed canonical sequence.

>Q5H9L2|TCEAL5
     1  MEKLYKENEG KPENERNLES EGKPEDEGST EDEGKSDEEE KPDMEGKTEC EGKREDEGEP
    61  GDEGQLEDEG NQEKQGKSEG EDKPQSEGKP ASQAKPESQP RAAEKRPAED YVPRKAKRKT
   121  DRGTDDSPKD SQEDLQERHL SSEEMMRECG DVSRAQEELR KKQKMGGFHW MQRDVQDPFA
   181  PRGQRGVRGV RGGGRGQKDL EDVPYV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TCEAL5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.69
Highest tissue expression: 114 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 114 nTPM
cerebral cortex: 107 nTPM
basal ganglia: 97 nTPM
hypothalamus: 82 nTPM
amygdala: 74 nTPM
hippocampal formation: 72 nTPM

Single-cell type

sertoli cells: 111 nCPM
müller glia: 54 nCPM
retinal amacrine cells: 28 nCPM
peritubular myoid cells: 27 nCPM
retinal bipolar cells: 26 nCPM
late spermatids: 25 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 71 nTPM
basal ganglia: 50 nTPM
cerebellum: 47 nTPM
hypothalamus: 47 nTPM
white matter: 46 nTPM
midbrain: 43 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.69
gnomAD pLI: 0.73
gnomAD missense Z: 1.12
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TCEAL5 as an antibody target. Whether an autoantibody or antibody against TCEAL5 could matter depends on whether native TCEAL5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TCEAL5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TCEAL5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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