Seroatlas · Human Serome Atlas

TCEAL4

Transcription elongation factor A protein-like 4

Also known as: FLJ21174, TCAL4_HUMAN, WEX7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96EI5
Gene: TCEAL4
Ensembl: ENSG00000133142
Chromosome: X
Canonical length: 215 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. This family is comprised of nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Multiple family members are located on the X chromosome. Alternatively splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 13. [provided by RefSeq, Apr 2015]

Canonical amino-acid sequenceUniProt

215 residues, UniProt reviewed canonical sequence.

>Q96EI5|TCEAL4
     1  MEKLYSENEG MASNQGKMEN EEQPQDERKP EVTCTLEDKK LENEGKTENK GKTGDEEMLK
    61  DKGKPESEGE AKEGKSEREG ESEMEGGSER EGKPEIEGKP ESEGEPGSET RAAGKRPAED
   121  DVPRKAKRKT NKGLAHYLKE YKEAIHDMNF SNEDMIREFD NMAKVQDEKR KSKQKLGAFL
   181  WMQRNLQDPF YPRGPREFRG GCRAPRRDIE DIPYV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TCEAL4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.68
Highest tissue expression: 821 nTPM

Expression across tissuesHPA

Tissue

ovary: 821 nTPM
endometrium: 663 nTPM
choroid plexus: 514 nTPM
cervix: 506 nTPM
blood vessel: 466 nTPM
urinary bladder: 452 nTPM

Single-cell type

peritubular myoid cells: 1,642 nCPM
decidual stromal cells: 1,538 nCPM
ovarian stromal cells: 1,413 nCPM
leydig cells: 1,164 nCPM
hepatic stellate cells: 1,052 nCPM
smooth muscle cells: 968 nCPM

Immune cell

T-reg: 57 nTPM
myeloid DC: 38 nTPM
memory B-cell: 37 nTPM
classical monocyte: 29 nTPM
NK-cell: 25 nTPM
naive B-cell: 23 nTPM

Brain region

choroid plexus: 188 nTPM
cerebral cortex: 124 nTPM
white matter: 107 nTPM
hypothalamus: 103 nTPM
medulla oblongata: 100 nTPM
pons: 98 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.66
gnomAD pLI: 0.75
gnomAD missense Z: 0.95
DepMap mean gene effect: 0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TCEAL4 as an antibody target. Whether an autoantibody or antibody against TCEAL4 could matter depends on whether native TCEAL4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TCEAL4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TCEAL4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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