Seroatlas · Human Serome Atlas

TCEAL3

Transcription elongation factor A protein-like 3

Also known as: MGC15737, TCAL3_HUMAN, WEX8

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q969E4
Gene: TCEAL3
Ensembl: ENSG00000196507
Chromosome: X
Canonical length: 200 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family contain TFA domains and may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

200 residues, UniProt reviewed canonical sequence.

>Q969E4|TCEAL3
     1  MEKPYNKNEG NLENEGKPED EVEPDDEGKS DEEEKPDVEG KTECEGKRED EGEPGDEGQL
    61  EDEGSQEKQG RSEGEGKPQG EGKPASQAKP ESQPRAAEKR PAEDYVPRKA KRKTDRGTDD
   121  SPKDSQEDLQ ERHLSSEEMM RECGDVSRAQ EELRKKQKMG GFHWMQRDVQ DPFAPRGQRG
   181  VRGVRGGGRG QRGLHDIPYL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TCEAL3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.69
Highest tissue expression: 213 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 213 nTPM
midbrain: 199 nTPM
blood vessel: 183 nTPM
hypothalamus: 173 nTPM
endometrium: 168 nTPM
ovary: 162 nTPM

Single-cell type

decidual stromal cells: 349 nCPM
smooth muscle cells: 319 nCPM
ovarian stromal cells: 261 nCPM
peritubular myoid cells: 234 nCPM
epididymal principal cells: 197 nCPM
epididymal basal cells: 196 nCPM

Immune cell

NK-cell: 20 nTPM
T-reg: 16 nTPM
MAIT T-cell: 14 nTPM
naive CD8 T-cell: 14 nTPM
gdT-cell: 13 nTPM
plasmacytoid DC: 12 nTPM

Brain region

midbrain: 90 nTPM
hypothalamus: 90 nTPM
cerebral cortex: 80 nTPM
pons: 79 nTPM
thalamus: 76 nTPM
medulla oblongata: 75 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.67
gnomAD pLI: 0.74
gnomAD missense Z: 1.09
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TCEAL3 as an antibody target. Whether an autoantibody or antibody against TCEAL3 could matter depends on whether native TCEAL3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TCEAL3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TCEAL3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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