Seroatlas · Human Serome Atlas

TCEAL2

Transcription elongation factor A protein-like 2

Also known as: my048, MY0876G05, TCAL2_HUMAN, WEX1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H3H9
Gene: TCEAL2
Ensembl: ENSG00000184905
Chromosome: X
Canonical length: 227 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles,Cytosol

OverviewNCBI Gene

This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family contain TFA domains and may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Multiple family members are located on the X chromosome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

227 residues, UniProt reviewed canonical sequence.

>Q9H3H9|TCEAL2
     1  MEKLFNENEG MPSNQGKIDN EEQPPHEGKP EVACILEDKK LENEGNTENT GKRVEEPLKD
    61  KEKPESAGKA KGEGKSERKG KSEMQGGSKT EGKPERGGRA EGEGEPDSER EPESEGEPES
   121  ETRAAGKRPA EDDIPRKAKR KTNKGLAQYL KQYKEAIHDM NFSNEDMIRE FDNMARVEDK
   181  RRKSKQKLGA FLWMQRNLQD PFYPRGPREF RGGCRAPRRD TEDIPYV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TCEAL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.67
Highest tissue expression: 243 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 243 nTPM
cerebral cortex: 234 nTPM
cerebellum: 220 nTPM
hypothalamus: 212 nTPM
amygdala: 186 nTPM
pituitary gland: 179 nTPM

Single-cell type

granulosa cells: 183 nCPM
müller glia: 128 nCPM
ovarian stromal cells: 106 nCPM
smooth muscle cells: 96 nCPM
sertoli cells: 95 nCPM
lacrimal acinar cells: 92 nCPM

Immune cell

naive CD8 T-cell: 0.4 nTPM
memory CD4 T-cell: 0.3 nTPM
naive CD4 T-cell: 0.3 nTPM
MAIT T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

cerebral cortex: 146 nTPM
hypothalamus: 100 nTPM
white matter: 95 nTPM
midbrain: 93 nTPM
pons: 85 nTPM
basal ganglia: 83 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.81
gnomAD pLI: 0.35
gnomAD missense Z: 0.12
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TCEAL2 as an antibody target. Whether an autoantibody or antibody against TCEAL2 could matter depends on whether native TCEAL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TCEAL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TCEAL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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