Seroatlas · Human Serome Atlas

TCAIM

T-cell activation inhibitor, mitochondrial

Also known as: C3orf23, DKFZp313N0621, TCAIM_HUMAN, TOAG-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N3R3
Gene: TCAIM
Ensembl: ENSG00000179152
Chromosome: 3
Canonical length: 496 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

496 residues, UniProt reviewed canonical sequence.

>Q8N3R3|TCAIM
     1  MFCHLRPMRR LCLEKIFPHW FPFSRALSGA EAVNALRPFY FAVHPDFFGQ HPVEREINEN
    61  SLKRLSVYLE NLQKPGFKSL KPTQLTFYVR ETDQSSSDGQ EPFSTSGFRA VKFTLHTRDL
   121  LSTVLYILNS CSLSVEHIQS LNTNMHTQPL KEAKRMPDRP IKWDKSYYSF TGFKDPDEDL
   181  EQVSRVETTL TSWLDNNGKS AVKKLKNSLP LRKELDRLKD ELSHQLQLSD IRWQRSWGIA
   241  HRCSQLHSLS RLAQQNLETL KKAKGCTIIF TDRSGMSAVG HVMLGTMDVH HHWTKLFERL
   301  PSYFDLQRRL MILEDQISYL LGGIQVVYIE ELQPVLTLEE YYSLLDVFYN RLLKSRILFH
   361  PRSLRGLQMI LNSDRYAPSL HELGHFNIPT LCDPANLQWF ILTKAQQARE NMKRKEELKV
   421  IENELIQAST KKFSLEKLYK EPSISSIQMV DCCKRLLEQS LPYLHGMHLC ISHFYSVMQD
   481  GDLCIPWNWK NGEAIK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TCAIM can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 40 nTPM

Expression across tissuesHPA

Tissue

liver: 40 nTPM
kidney: 23 nTPM
skeletal muscle: 21 nTPM
heart muscle: 18 nTPM
tongue: 18 nTPM
spinal cord: 14 nTPM

Single-cell type

distal convoluted tubule cells: 243 nCPM
myonuclei: 200 nCPM
choroid plexus epithelial cells: 161 nCPM
podocytes: 159 nCPM
loop of henle epithelial cells: 151 nCPM
renal connecting tubule cells: 151 nCPM

Immune cell

basophil: 15 nTPM
eosinophil: 11 nTPM
myeloid DC: 10 nTPM
non-classical monocyte: 10 nTPM
intermediate monocyte: 10 nTPM
T-reg: 9.4 nTPM

Brain region

cerebellum: 24 nTPM
white matter: 21 nTPM
medulla oblongata: 20 nTPM
pons: 19 nTPM
thalamus: 19 nTPM
midbrain: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.75
gnomAD pLI: 0
gnomAD missense Z: 1.3
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

mitochondrion

Protein domainsUniProt · Pfam · InterPro

T-cell activation inhibitor, mitochondrial
Domain of unknown function DUF4461
Domain of unknown function DUF4460
Domain of unknown function (DUF4460)
Domain of unknown function (DUF4461)

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TCAIM as an antibody target. Whether an autoantibody or antibody against TCAIM could matter depends on whether native TCAIM is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TCAIM is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TCAIM as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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