Seroatlas · Human Serome Atlas

TCAF2

TRPM8 channel-associated factor 2

Also known as: FAM115C, FAM139A, FLJ40722, GATD9B, TCAF2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NFQ2
Gene: TCAF2
Ensembl: ENSG00000170379
Chromosome: 7
Canonical length: 919 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Cell Junctions

OverviewNCBI Gene

Enables transmembrane transporter binding activity. Involved in negative regulation of anion channel activity; positive regulation of cell migration; and positive regulation of protein targeting to membrane. Located in cell junction and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

919 residues, UniProt reviewed canonical sequence.

>A6NFQ2|TCAF2
     1  MATIAAAAFE ALMDGVTCWD VPRGPIPSEL LLIGEAAFPV MVNDKGQVLI AASSYGRGRL
    61  VVVSHEGYLS HTGLAPFLLN AVSWLCPCPG APVGVHPSLA PLVNILQDAG LEAQVKPEPG
   121  EPLGVYCINA YNDTLTATLI QFVKHGGGLL IGGQAWYWAS QHGPDKVLSR FPGNKVTSVA
   181  GVYFTDTYGD RDRFKVSKKV PKIPLHVRYG EDVRQDQQQL LEGISELDIR TGGVPSQLLV
   241  HGALAFPLGL DASLNCFLAA AHYGRGRVVL AAHECLLCAP KMGPFLLNAV RWLARGQTGK
   301  VGVNTNLKDL CPLLSEHGLQ CSLEPHLNSD LCVYCCKAYS DKEAKQLQEF VAEGGGLLIG
   361  GQAWWWASQN PGHCPLAGFP GNIILNCFGL SILPQTLKAG CFPVPTPEMR SYHFRKALSQ
   421  FQAILNHENG NLEKSCLAKL RVDGAAFLQI PAEGVPAYIS LHRLLRKMLR GSGLPAVSRE
   481  NPVASDSYEA AVLSLATGLA HSGTDCSQLA QGLGTWTCSS SLYPSKHPIT VEINGINPGN
   541  NDCWVSTGLY LLEGQNAEVS LSEAAASAGL RVQIGCHTDD LTKARKLSRA PVVTHQCWMD
   601  RTERSVSCLW GGLLYVIVPK GSQLGPVPVT IRGAVPAPYY KLGKTSLEEW KRQMQENLAP
   661  WGELATDNII LTVPTTNLQA LKDPEPVLRL WDEMMQAVAR LAAEPFPFRR PERIVADVQI
   721  SAGWMHSGYP IMCHLESVKE IINEMDMRSR GVWGPIHELG HNQQRHGWEF PPHTTEATCN
   781  LWSVYVHETV LGIPRAQAHE ALSPPERERR IKAHLGKGAP LCDWNVWTAL ETYLQLQEAF
   841  GWEPFTQLFA EYQTLSHLPK DNTGRMNLWV KKFSEKVKKN LVPFFEAWGW PIQKEVADSL
   901  ASLPEWQENP MQVYLRARK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TCAF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.22
Highest tissue expression: 7.1 nTPM

Expression across tissuesHPA

Tissue

esophagus: 7.1 nTPM
breast: 5.4 nTPM
placenta: 5 nTPM
vagina: 4.8 nTPM
liver: 4.2 nTPM
cervix: 4.1 nTPM

Single-cell type

renal connecting tubule cells: 30 nCPM
papillary tip epithelial cells: 25 nCPM
podocytes: 21 nCPM
renal collecting duct principal cells: 19 nCPM
renal collecting duct intercalated cells: 16 nCPM
proximal tubule cells: 7.6 nCPM

Immune cell

T-reg: 6.6 nTPM
basophil: 6.1 nTPM
memory CD4 T-cell: 5.5 nTPM
naive CD4 T-cell: 4.9 nTPM
naive CD8 T-cell: 3.7 nTPM
MAIT T-cell: 3.6 nTPM

Brain region

cerebellum: 19 nTPM
cerebral cortex: 16 nTPM
midbrain: 15 nTPM
white matter: 15 nTPM
medulla oblongata: 14 nTPM
pons: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.92
gnomAD pLI: 0

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

transmembrane transporter binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TCAF2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TCAF2 as an antibody target. Whether an autoantibody or antibody against TCAF2 could matter depends on whether native TCAF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TCAF2 is annotated at the cell surface, where native TCAF2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TCAF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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