Seroatlas · Human Serome Atlas

TCAF1

TRPM8 channel-associated factor 1

Also known as: FAM115A, GATD9A, KIAA0738, TCAF1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y4C2
Gene: TCAF1
Ensembl: ENSG00000198420
Chromosome: 7
Canonical length: 921 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear bodies,Vesicles,Cell Junctions

OverviewNCBI Gene

Enables transmembrane transporter binding activity. Involved in negative regulation of cell migration; positive regulation of anion channel activity; and positive regulation of protein targeting to membrane. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

921 residues, UniProt reviewed canonical sequence.

>Q9Y4C2|TCAF1
     1  MATPSAAFEA LMNGVTSWDV PEDAVPCELL LIGEASFPVM VNDMGQVLIA ASSYGRGRLV
    61  VVSHEDYLVE AQLTPFLLNA VGWLCSSPGA PIGVHPSLAP LAKILEGSGV DAKVEPEVKD
   121  SLGVYCIDAY NETMTEKLVK FMKCGGGLLI GGQAWDWANQ GEDERVLFTF PGNLVTSVAG
   181  IYFTDNKGDT SFFKVSKKMP KIPVLVSCED DLSDDREELL HGISELDISN SDCFPSQLLV
   241  HGALAFPLGL DSYHGCVIAA ARYGRGRVVV TGHKVLFTVG KLGPFLLNAV RWLDGGRRGK
   301  VVVQTELRTL SGLLAVGGID TSIEPNLTSD ASVYCFEPVS EVGVKELQEF VAEGGGLFVG
   361  AQAWWWAFKN PGVSPLARFP GNLLLNPFGI SITSQSLNPG PFRTPKAGIR TYHFRSTLAE
   421  FQVIMGRKRG NVEKGWLAKL GPDGAAFLQI PAEEIPAYMS VHRLLRKLLS RYRLPVATRE
   481  NPVINDCCRG AMLSLATGLA HSGSDLSLLV PEIEDMYSSP YLRPSESPIT VEVNCTNPGT
   541  RYCWMSTGLY IPGRQIIEVS LPEAAASADL KIQIGCHTDD LTRASKLFRG PLVINRCCLD
   601  KPTKSITCLW GGLLYIIVPQ NSKLGSVPVT VKGAVHAPYY KLGETTLEEW KRRIQENPGP
   661  WGELATDNII LTVPTANLRT LENPEPLLRL WDEVMQAVAR LGAEPFPLRL PQRIVADVQI
   721  SVGWMHAGYP IMCHLESVQE LINEKLIRTK GLWGPVHELG RNQQRQEWEF PPHTTEATCN
   781  LWCVYVHETV LGIPRSRANI ALWPPVREKR VRIYLSKGPN VKNWNAWTAL ETYLQLQEAF
   841  GWEPFIRLFT EYRNQTNLPT ENVDKMNLWV KMFSHQVQKN LAPFFEAWAW PIQKEVATSL
   901  AYLPEWKENI MKLYLLTQMP H

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TCAF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.22
Highest tissue expression: 76 nTPM

Expression across tissuesHPA

Tissue

placenta: 76 nTPM
basal ganglia: 54 nTPM
tongue: 52 nTPM
ovary: 47 nTPM
cerebral cortex: 45 nTPM
adrenal gland: 44 nTPM

Single-cell type

brain inhibitory neurons: 78 nCPM
podocytes: 78 nCPM
brain excitatory neurons: 61 nCPM
other brain neurons: 60 nCPM
oligodendrocyte progenitor cells: 52 nCPM
distal convoluted tubule cells: 52 nCPM

Immune cell

gdT-cell: 4.7 nTPM
NK-cell: 4.4 nTPM
MAIT T-cell: 3.3 nTPM
memory CD8 T-cell: 3.1 nTPM
non-classical monocyte: 3.1 nTPM
naive CD8 T-cell: 3 nTPM

Brain region

basal ganglia: 149 nTPM
hypothalamus: 132 nTPM
cerebral cortex: 105 nTPM
hippocampal formation: 103 nTPM
pons: 85 nTPM
white matter: 81 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.54
gnomAD pLI: 0.62
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TCAF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TCAF1 as an antibody target. Whether an autoantibody or antibody against TCAF1 could matter depends on whether native TCAF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TCAF1 is annotated at the cell surface, where native TCAF1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TCAF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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