Seroatlas · Human Serome Atlas

TBCK

TBC domain-containing protein kinase-like protein

Also known as: HSPC302, MGC16169, TBCK_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TEA7
Gene
TBCK
Ensembl
ENSG00000145348
Chromosome
4
Canonical length
893 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nucleoli fibrillar center

OverviewNCBI Gene

This gene encodes a protein that contains a protein kinase domain, a Rhodanase-like domain and the Tre-2/Bub2/Cdc16 (TBC) domain. The encoded protein is thought to play a role in actin organization, cell growth and cell proliferation by regulating the mammalian target of the rapamycin (mTOR) signaling pathway. This protein may also be involved in the transcriptional regulation of the components of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Canonical amino-acid sequenceUniProt

893 residues, UniProt reviewed canonical sequence.

>Q8TEA7|TBCK
     1  MFPLKDAEMG AFTFFASALP HDVCGSNGLP LTPNSIKILG RFQILKTITH PRLCQYVDIS
    61  RGKHERLVVV AEHCERSLED LLRERKPVSC STVLCIAFEV LQGLQYMNKH GIVHRALSPH
   121  NILLDRKGHI KLAKFGLYHM TAHGDDVDFP IGYPSYLAPE VIAQGIFKTT DHMPSKKPLP
   181  SGPKSDVWSL GIILFELCVG RKLFQSLDIS ERLKFLLTLD CVDDTLIVLA EEHGCLDIIK
   241  ELPETVIDLL NKCLTFHPSK RPTPDQLMKD KVFSEVSPLY TPFTKPASLF SSSLRCADLT
   301  LPEDISQLCK DINNDYLAER SIEEVYYLWC LAGGDLEKEL VNKEIIRSKP PICTLPNFLF
   361  EDGESFGQGR DRSSLLDDTT VTLSLCQLRN RLKDVGGEAF YPLLEDDQSN LPHSNSNNEL
   421  SAAATLPLII REKDTEYQLN RIILFDRLLK AYPYKKNQIW KEARVDIPPL MRGLTWAALL
   481  GVEGAIHAKY DAIDKDTPIP TDRQIEVDIP RCHQYDELLS SPEGHAKFRR VLKAWVVSHP
   541  DLVYWQGLDS LCAPFLYLNF NNEALAYACM SAFIPKYLYN FFLKDNSHVI QEYLTVFSQM
   601  IAFHDPELSN HLNEIGFIPD LYAIPWFLTM FTHVFPLHKI FHLWDTLLLG NSSFPFCIGV
   661  AILQQLRDRL LANGFNECIL LFSDLPEIDI ERCVRESINL FCWTPKSATY RQHAQPPKPS
   721  SDSSGGRSSA PYFSAECPDP PKTDLSRESI PLNDLKSEVS PRISAEDLID LCELTVTGHF
   781  KTPSKKTKSS KPKLLVVDIR NSEDFIRGHI SGSINIPFSA AFTAEGELTQ GPYTAMLQNF
   841  KGKVIVIVGH VAKHTAEFAA HLVKMKYPRI CILDGGINKI KPTGLLTIPS PQI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TBCK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
8.5 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 8.5 nTPM
  • retina: 7 nTPM
  • adipose tissue: 6.9 nTPM
  • adrenal gland: 6.2 nTPM
  • kidney: 5.9 nTPM
  • choroid plexus: 5.7 nTPM

Single-cell type

  • choroid plexus epithelial cells: 373 nCPM
  • gonadotrophs: 317 nCPM
  • distal convoluted tubule cells: 309 nCPM
  • thyrotrophs: 307 nCPM
  • lactotrophs: 302 nCPM
  • somatotrophs: 289 nCPM

Immune cell

  • basophil: 14 nTPM
  • naive B-cell: 8 nTPM
  • memory CD8 T-cell: 6.4 nTPM
  • intermediate monocyte: 5.7 nTPM
  • MAIT T-cell: 5.5 nTPM
  • naive CD4 T-cell: 5.5 nTPM

Brain region

  • cerebellum: 44 nTPM
  • white matter: 40 nTPM
  • choroid plexus: 39 nTPM
  • hypothalamus: 35 nTPM
  • cerebral cortex: 34 nTPM
  • medulla oblongata: 33 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TBCK.

Disease | AllUniProt

Conditions TBCK is implicated in, by any mechanism.

  • Hypotonia, infantile, with psychomotor retardation and characteristic facies 3 (IHPRF3) MIM:616900

Disease | GeneticClinVar

102 pathogenic / likely-pathogenic of 930 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.87
gnomAD pLI
0
gnomAD missense Z
0.5
DepMap mean gene effect
0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TBCK as an antibody target. Whether an autoantibody or antibody against TBCK could matter depends on whether native TBCK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TBCK is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TBCK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TBCK. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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