TBCC

Protein identityUniProt · HPA

UniProt accession

Q15814

Gene

TBCC

Ensembl

ENSG00000124659

Chromosome

6

Canonical length

346 aa

Protein class

Plasma proteins, Predicted intracellular proteins

Subcellular location

Cytosol

OverviewNCBI Gene

Cofactor C is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

346 residues, UniProt reviewed canonical sequence.

>Q15814|TBCC
     1  MESVSCSAAA VRTGDMESQR DLSLVPERLQ RREQERQLEV ERRKQKRQNQ EVEKENSHFF
    61  VATFVRERAA VEELLERAES VERLEEAASR LQGLQKLIND SVFFLAAYDL RQGQEALARL
   121  QAALAERRRG LQPKKRFAFK TRGKDAASST KVDAAPGIPP AVESIQDSPL PKKAEGDLGP
   181  SWVCGFSNLE SQVLEKRASE LHQRDVLLTE LSNCTVRLYG NPNTLRLTKA HSCKLLCGPV
   241  STSVFLEDCS DCVLAVACQQ LRIHSTKDTR IFLQVTSRAI VEDCSGIQFA PYTWSYPEID
   301  KDFESSGLDR SKNNWNDVDD FNWLARDMAS PNWSILPEEE RNIQWD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TBCC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.38

Highest tissue expression

37 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.5

gnomAD pLI

0

gnomAD missense Z

-0.61

DepMap mean gene effect

-0.84

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• post-chaperonin tubulin folding pathway
• protein folding
• tubulin complex assembly

Molecular functions

• GTPase activity
• protein-folding chaperone binding
• tubulin binding

Cellular components

• cytoplasm
• cytoskeleton
• cytosol
• endoplasmic reticulum
• microtubule
• photoreceptor connecting cilium

Protein domainsUniProt · Pfam · InterPro

• CARP motif
• Tubulin binding cofactor C-like domain
• Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal
• C-CAP/cofactor C-like domain
• Tubulin binding cofactor C
• Tubulin-specific chaperone C
• Tubulin-specific chaperone C, N-terminal
• TBCC, N-terminal domain superfamily
• Tubulin-specific chaperone C N-terminal domain

KeywordsUniProt

• Acetylation
• Chaperone
• Cytoplasm
• Phosphoprotein