Seroatlas · Human Serome Atlas

TBC1D9B

TBC1 domain family member 9B

Also known as: GRAMD9B, KIAA0676, TBC9B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q66K14
Gene: TBC1D9B
Ensembl: ENSG00000197226
Chromosome: 5
Canonical length: 1250 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli fibrillar center,Plasma membrane,Actin filaments

OverviewNCBI Gene

Predicted to enable GTPase activator activity. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1250 residues, UniProt reviewed canonical sequence.

>Q66K14|TBC1D9B
     1  MWLSPEEVLV ANALWVTERA NPFFVLQRRR GHGRGGGLTG LLVGTLDVVL DSSARVAPYR
    61  ILHQTQDSQV YWTVACGSSR KEITKHWEWL ENNLLQTLSI FDSEEDITTF VKGKIHGIIA
   121  EENKNLQPQG DEDPGKFKEA ELKMRKQFGM PEGEKLVNYY SCSYWKGRVP RQGWLYLTVN
   181  HLCFYSFLLG KEVSLVVQWV DITRLEKNAT LLFPESIRVD TRDQELFFSM FLNIGETFKL
   241  MEQLANLAMR QLLDSEGFLE DKALPRPIRP HRNISALKRD LDARAKNECY RATFRLPRDE
   301  RLDGHTSCTL WTPFNKLHIP GQMFISNNYI CFASKEEDAC HLIIPLREVT IVEKADSSSV
   361  LPSPLSISTK SKMTFLFANL KDRDFLVQRI SDFLQKTPSK QPGSIGSRKA SVVDPSTESS
   421  PAPQEGSEQP ASPASPLSSR QSFCAQEAPT ASQGLLKLFQ KNSPMEDLGA KGAKEKMKEE
   481  SWHIHFFEYG RGVCMYRTAK TRALVLKGIP ESLRGELWLL FSGAWNEMVT HPGYYAELVE
   541  KSTGKYSLAT EEIERDLHRS MPEHPAFQNE LGIAALRRVL TAYAFRNPTI GYCQAMNIVT
   601  SVLLLYGSEE EAFWLLVALC ERMLPDYYNT RVVGALVDQG IFEELTRDFL PQLSEKMQDL
   661  GVISSISLSW FLTLFLSVMP FESAVVIVDC FFYEGIKVIL QVALAVLDAN MEQLLGCSDE
   721  GEAMTMLGRY LDNVVNKQSV SPPIPHLRAL LSSSDDPPAE VDIFELLKVS YEKFSSLRAE
   781  DIEQMRFKQR LKVIQSLEDT AKRSVVRAIP VDIGFSIEEL EDLYMVFKAK HLASQYWGCS
   841  RTMAGRRDPS LPYLEQYRID ASQFRELFAS LTPWACGSHT PLLAGRMFRL LDENKDSLIN
   901  FKEFVTGMSG MYHGDLTEKL KVLYKLHLPP ALSPEEAESA LEAAHYFTED SSSEASPLAS
   961  DLDLFLPWEA QEALPQEEQE GSGSEERGEE KGTSSPDYRH YLRMWAKEKE AQKETIKDLP
  1021  KMNQEQFIEL CKTLYNMFSE DPMEQDLYHA IATVASLLLR IGEVGKKFSA RTGRKPRDCA
  1081  TEEDEPPAPE LHQDAARELQ PPAAGDPQAK AGGDTHLGKA PQESQVVVEG GSGEGQGSPS
  1141  QLLSDDETKD DMSMSSYSVV STGSLQCEDL ADDTVLVGGE ACSPTARIGG TVDTDWCISF
  1201  EQILASILTE SVLVNFFEKR VDIGLKIKDQ KKVERQFSTA SDHEQPGVSG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TBC1D9B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 95 nTPM

Expression across tissuesHPA

Tissue

spinal cord: 95 nTPM
midbrain: 78 nTPM
amygdala: 69 nTPM
hippocampal formation: 69 nTPM
basal ganglia: 66 nTPM
cerebral cortex: 66 nTPM

Single-cell type

podocytes: 51 nCPM
microglia: 46 nCPM
brain excitatory neurons: 44 nCPM
proximal tubule cells: 34 nCPM
renal collecting duct principal cells: 34 nCPM
oligodendrocytes: 32 nCPM

Immune cell

plasmacytoid DC: 9.5 nTPM
myeloid DC: 9.3 nTPM
non-classical monocyte: 9.3 nTPM
intermediate monocyte: 9.2 nTPM
classical monocyte: 7.8 nTPM
total PBMC: 7.1 nTPM

Brain region

white matter: 114 nTPM
spinal cord: 113 nTPM
pons: 109 nTPM
basal ganglia: 107 nTPM
medulla oblongata: 106 nTPM
midbrain: 103 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.66
gnomAD pLI: 0
gnomAD missense Z: 0.64
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

system process

Molecular functions

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TBC1D9B as an antibody target. Whether an autoantibody or antibody against TBC1D9B could matter depends on whether native TBC1D9B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TBC1D9B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TBC1D9B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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