Seroatlas · Human Serome Atlas

TBC1D9

TBC1 domain family member 9

Also known as: GRAMD9, KIAA0882, MDR1, TBCD9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZT07
Gene: TBC1D9
Ensembl: ENSG00000109436
Chromosome: 4
Canonical length: 1266 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to enable GTPase activator activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1266 residues, UniProt reviewed canonical sequence.

>Q6ZT07|TBC1D9
     1  MWVNPEEVLL ANALWITERA NPYFILQRRK GHAGDGGGGG GLAGLLVGTL DVVLDSSARV
    61  APYRILYQTP DSLVYWTIAC GGSRKEITEH WEWLEQNLLQ TLSIFENEND ITTFVRGKIQ
   121  GIIAEYNKIN DVKEDDDTEK FKEAIVKFHR LFGMPEEEKL VNYYSCSYWK GKVPRQGWMY
   181  LSINHLCFYS FLMGREAKLV IRWVDITQLE KNATLLLPDV IKVSTRSSEH FFSVFLNINE
   241  TFKLMEQLAN IAMRQLLDNE GFEQDRSLPK LKRKSPKKVS ALKRDLDARA KSERYRALFR
   301  LPKDEKLDGH TDCTLWTPFN KMHILGQMFV STNYICFTSK EENLCSLIIP LREVTIVEKA
   361  DSSSVLPSPL SISTRNRMTF LFANLKDRDF LVQRISDFLQ QTTSKIYSDK EFAGSYNSSD
   421  DEVYSRPSSL VSSSPQRSTS SDADGERQFN LNGNSVPTAT QTLMTMYRRR SPEEFNPKLA
   481  KEFLKEQAWK IHFAEYGQGI CMYRTEKTRE LVLKGIPESM RGELWLLLSG AINEKATHPG
   541  YYEDLVEKSM GKYNLATEEI ERDLHRSLPE HPAFQNEMGI AALRRVLTAY AFRNPNIGYC
   601  QAMNIVTSVL LLYAKEEEAF WLLVALCERM LPDYYNTRVV GALVDQGVFE ELARDYVPQL
   661  YDCMQDLGVI STISLSWFLT LFLSVMPFES AVVVVDCFFY EGIKVIFQLA LAVLDANVDK
   721  LLNCKDDGEA MTVLGRYLDS VTNKDSTLPP IPHLHSLLSD DVEPYPEVDI FRLIRTSYEK
   781  FGTIRADLIE QMRFKQRLKV IQTLEDTTKR NVVRTIVTET SFTIDELEEL YALFKAEHLT
   841  SCYWGGSSNA LDRHDPSLPY LEQYRIDFEQ FKGMFALLFP WACGTHSDVL ASRLFQLLDE
   901  NGDSLINFRE FVSGLSAACH GDLTEKLKLL YKMHVLPEPS SDQDEPDSAF EATQYFFEDI
   961  TPECTHVVGL DSRSKQGADD GFVTVSLKPD KGKRANSQEN RNYLRLWTPE NKSKSKNAKD
  1021  LPKLNQGQFI ELCKTMYNMF SEDPNEQELY HATAAVTSLL LEIGEVGKLF VAQPAKEGGS
  1081  GGSGPSCHQG IPGVLFPKKG PGQPYVVESV EPLPASLAPD SEEHSLGGQM EDIKLEDSSP
  1141  RDNGACSSML ISDDDTKDDS SMSSYSVLSA GSHEEDKLHC EDIGEDTVLV RSGQGTAALP
  1201  RSTSLDRDWA ITFEQFLASL LTEPALVKYF DKPVCMMARI TSAKNIRMMG KPLTSASDYE
  1261  ISAMSG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TBC1D9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 46 nTPM

Expression across tissuesHPA

Tissue

breast: 46 nTPM
cerebellum: 36 nTPM
spleen: 32 nTPM
seminal vesicle: 20 nTPM
choroid plexus: 20 nTPM
retina: 20 nTPM

Single-cell type

distal convoluted tubule cells: 490 nCPM
renal connecting tubule cells: 359 nCPM
plasma cells: 289 nCPM
microglia: 280 nCPM
endometrial luminal cells: 256 nCPM
breast hormone-responsive cells: 246 nCPM

Immune cell

memory B-cell: 5.9 nTPM
plasmacytoid DC: 3.2 nTPM
naive B-cell: 3 nTPM
myeloid DC: 2.9 nTPM
classical monocyte: 1.7 nTPM
intermediate monocyte: 1.3 nTPM

Brain region

choroid plexus: 92 nTPM
cerebellum: 63 nTPM
hypothalamus: 49 nTPM
pons: 49 nTPM
thalamus: 44 nTPM
midbrain: 37 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.49
gnomAD pLI: 0
gnomAD missense Z: 3.16
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

system process

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TBC1D9 as an antibody target. Whether an autoantibody or antibody against TBC1D9 could matter depends on whether native TBC1D9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TBC1D9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TBC1D9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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