Seroatlas · Human Serome Atlas

TBC1D8

TBC1 domain family member 8

Also known as: AD3, GRAMD8, HBLP1, TBCD8_HUMAN, VRP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95759
Gene: TBC1D8
Ensembl: ENSG00000204634
Chromosome: 2
Canonical length: 1140 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Plasma membrane,Centrosome

OverviewNCBI Gene

Predicted to enable GTPase activator activity. Predicted to be involved in blood circulation and positive regulation of cell population proliferation. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1140 residues, UniProt reviewed canonical sequence.

>O95759|TBC1D8
     1  MWLKPEEVLL KNALKLWVTQ KSSCYFILQR RRGHGEGGGR LTGRLVGALD AVLDSNARVA
    61  PFRILLQVPG SQVYSPIACG ATLEEINQHW DWLEQNLLHT LSVFDNKDDI ASFVKGKVKA
   121  LIAEETSSRL AEQEEEPEKF REALVKFEAR FNFPEAEKLV TYYSCCCWKG RVPRQGWLYL
   181  SINHLCFYSF FLGKELKLVV PWVDIQKLER TSNVFLTDTI RITTQNKERD FSMFLNLDEV
   241  FKVMEQLADV TLRRLLDNEV FDLDPDLQEP SQITKRDLEA RAQNEFFRAF FRLPRKEKLH
   301  AVVDCSLWTP FSRCHTTGRM FASDSYICFA SREDGCCKII LPLREVVSIE KMEDTSLLPH
   361  PIIVSIRSKV AFQFIELRDR DSLVEALLAR LKQVHANHPV HYDTSADDDM ASLVFHSTSM
   421  CSDHRFGDLE MMSSQNSEES EKEKSPLMHP DALVTAFQQS GSQSPDSRMS REQIKISLWN
   481  DHFVEYGRTV CMFRTEKIRK LVAMGIPESL RGRLWLLFSD AVTDLASHPG YYGNLVEESL
   541  GKCCLVTEEI ERDLHRSLPE HPAFQNETGI AALRRVLTAY AHRNPKIGYC QSMNILTSVL
   601  LLYTKEEEAF WLLVAVCERM LPDYFNHRVI GAQVDQSVFE ELIKGHLPEL AEHMNDLSAL
   661  ASVSLSWFLT LFLSIMPLES AVNVVDCFFY DGIKAIFQLG LAVLEANAED LCSSKDDGQA
   721  LMILSRFLDH IKNEDSPGPP VGSHHAFFSD DQEPYPVTDI SDLIRDSYEK FGDQSVEQIE
   781  HLRYKHRIRV LQGHEDTTKQ NVLRVVIPEV SILPEDLEEL YDLFKREHMM SCYWEQPRPM
   841  ASRHDPSRPY AEQYRIDARQ FAHLFQLVSP WTCGAHTEIL AERTFRLLDD NMDQLIEFKA
   901  FVSCLDIMYN GEMNEKIKLL YRLHIPPALT ENDRDSQSPL RNPLLSTSRP LVFGKPNGDA
   961  VDYQKQLKQM IKDLAKEKDK TEKELPKMSQ REFIQFCKTL YSMFHEDPEE NDLYQAIATV
  1021  TTLLLQIGEV GQRGSSSGSC SQECGEELRA SAPSPEDSVF ADTGKTPQDS QAFPEAAERD
  1081  WTVSLEHILA SLLTEQSLVN FFEKPLDMKS KLENAKINQY NLKTFEMSHQ SQSELKLSNL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TBC1D8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 85 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 85 nTPM
tongue: 75 nTPM
prostate: 47 nTPM
heart muscle: 36 nTPM
pancreas: 36 nTPM
small intestine: 30 nTPM

Single-cell type

breast lactating cells: 1,029 nCPM
myonuclei: 813 nCPM
neutrophils: 695 nCPM
prostatic glandular cells: 612 nCPM
endometrial glandular cells: 585 nCPM
endometrial ciliated cells: 527 nCPM

Immune cell

non-classical monocyte: 38 nTPM
intermediate monocyte: 30 nTPM
classical monocyte: 9.7 nTPM
plasmacytoid DC: 7.3 nTPM
myeloid DC: 5 nTPM
total PBMC: 4.1 nTPM

Brain region

cerebellum: 19 nTPM
choroid plexus: 18 nTPM
pons: 15 nTPM
hypothalamus: 14 nTPM
medulla oblongata: 14 nTPM
thalamus: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.7
gnomAD pLI: 0
gnomAD missense Z: 1.39
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

GTPase activator activity

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TBC1D8 as an antibody target. Whether an autoantibody or antibody against TBC1D8 could matter depends on whether native TBC1D8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TBC1D8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TBC1D8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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