Seroatlas · Human Serome Atlas

TBC1D30

TBC1 domain family member 30

Also known as: KIAA0984, TBC30_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y2I9
Gene
TBC1D30
Ensembl
ENSG00000111490
Chromosome
12
Canonical length
924 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Plasma membrane,Mid piece,Principal piece

OverviewNCBI Gene

Enables GTPase activator activity and small GTPase binding activity. Involved in negative regulation of cilium assembly and positive regulation of GTPase activity. Located in several cellular components, including ciliary basal body; cytosol; and nuclear body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

924 residues, UniProt reviewed canonical sequence.

>Q9Y2I9|TBC1D30
     1  MDVLPTGGGR PGLRTELEFR GGGGEARLES QEEETIPAAP PAPRLRGAAE RPRRSRDTWD
    61  GDEDTEPGEA CGGRTSRTAS LVSGLLNELY SCTEEEEAAG GGRGAEGRRR RRDSLDSSTE
   121  ASGSDVVLGG RSGAGDSRVL QELQERPSQR HQMLYLRQKD ANELKTILRE LKYRIGIQSA
   181  KLLRHLKQKD RLLHKVQRNC DIVTACLQAV SQKRRVDTKL KFTLEPSLGQ NGFQQWYDAL
   241  KAVARLSTGI PKEWRRKVWL TLADHYLHSI AIDWDKTMRF TFNERSNPDD DSMGIQIVKD
   301  LHRTGCSSYC GQEAEQDRVV LKRVLLAYAR WNKTVGYCQG FNILAALILE VMEGNEGDAL
   361  KIMIYLIDKV LPESYFVNNL RALSVDMAVF RDLLRMKLPE LSQHLDTLQR TANKESGGGY
   421  EPPLTNVFTM QWFLTLFATC LPNQTVLKIW DSVFFEGSEI ILRVSLAIWA KLGEQIECCE
   481  TADEFYSTMG RLTQEMLEND LLQSHELMQT VYSMAPFPFP QLAELREKYT YNITPFPATV
   541  KPTSVSGRHS KARDSDEEND PDDEDAVVNA VGCLGPFSGF LAPELQKYQK QIKEPNEEQS
   601  LRSNNIAELS PGAINSCRSE YHAAFNSMMM ERMTTDINAL KRQYSRIKKK QQQQVHQVYI
   661  RADKGPVTSI LPSQVNSSPV INHLLLGKKM KMTNRAAKNA VIHIPGHTGG KISPVPYEDL
   721  KTKLNSPWRT HIRVHKKNMP RTKSHPGCGD TVGLIDEQNE ASKTNGLGAA EAFPSGCTAT
   781  AGREGSSPEG STRRTIEGQS PEPVFGDADV DVSAVQAKLG ALELNQRDAA AETELRVHPP
   841  CQRHCPEPPS APEENKATSK APQGSNSKTP IFSPFPSVKP LRKSATARNL GLYGPTERTP
   901  TVHFPQMSRS FSKPGGGNSG TKKR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TBC1D30 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
10 nTPM

Expression across tissuesHPA

Tissue

  • pancreas: 10 nTPM
  • cerebellum: 7.9 nTPM
  • cerebral cortex: 6.5 nTPM
  • salivary gland: 6.4 nTPM
  • pituitary gland: 6.1 nTPM
  • stomach: 3.4 nTPM

Single-cell type

  • choroid plexus epithelial cells: 141 nCPM
  • brain inhibitory neurons: 51 nCPM
  • renal collecting duct principal cells: 50 nCPM
  • brain excitatory neurons: 45 nCPM
  • renal connecting tubule cells: 44 nCPM
  • other brain neurons: 35 nCPM

Immune cell

  • neutrophil: 0.2 nTPM
  • classical monocyte: 0.1 nTPM
  • intermediate monocyte: 0.1 nTPM
  • non-classical monocyte: 0.1 nTPM
  • basophil: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • cerebral cortex: 34 nTPM
  • pons: 27 nTPM
  • hippocampal formation: 24 nTPM
  • cerebellum: 23 nTPM
  • medulla oblongata: 20 nTPM
  • white matter: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.35
gnomAD pLI
0.89
gnomAD missense Z
2.7
DepMap mean gene effect
-0.21
DepMap dependency class
selective

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TBC1D30 as an antibody target. Whether an autoantibody or antibody against TBC1D30 could matter depends on whether native TBC1D30 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TBC1D30 is annotated at the cell surface, where native TBC1D30 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TBC1D30 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TBC1D30. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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