Seroatlas · Human Serome Atlas

TBC1D19

TBC1 domain family member 19

Also known as: FLJ11082, TBC19_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N5T2
Gene: TBC1D19
Ensembl: ENSG00000109680
Chromosome: 4
Canonical length: 526 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Nuclear membrane

OverviewNCBI Gene

Predicted to enable GTPase activator activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

526 residues, UniProt reviewed canonical sequence.

>Q8N5T2|TBC1D19
     1  MLQEESDLSL IIAQIVQKLK GSNLYSQLER QAWASLQRPE IKLESLKEDI KEFFKISGWE
    61  KKLQNAVYSE LSVFPLPSHP AAPPEHLKEP LVYMRKAQGS WEKRILKSLN SMCTELSIPL
   121  ARKRPVGEQK ELLNKWNEMG TDEPDLSLFR PVYAPKDFLE VLINLRNPNY ENGDSLSFRT
   181  HLGLIQVPLK VKDIPELKEC FVELGLNIGQ LGIDDSTQVP PELFENEHVR IGQKVLAEQD
   241  SAAAQQYIRQ GSPTALRAEL WALILNISSQ PEDVLYYEQL KTNVIQHDLL VDSLIYKDVK
   301  LTASNDDYYF VFEDYLYQVL LCFSRDTSVL SHFAFNSASP PKSYIRGKLG LEEYAVFYPP
   361  NGVIPFHGFS MYVAPLCFLY HEPSKLYQIF REMYVRFFFR LHSISSHPSG IVSLCLLFET
   421  LLQTYLPQLF YHLREIGAQP LRISFKWMVR AFSGYLATDQ LLLLWDRILG YNSLEILAVL
   481  AAAVFAFRAV NLMEVTSLAA AEAVLADLST LKVMPLLQIF LFATVT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TBC1D19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.25
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

kidney: 16 nTPM
thymus: 16 nTPM
parathyroid gland: 14 nTPM
choroid plexus: 10 nTPM
retina: 8.5 nTPM
smooth muscle: 8.2 nTPM

Single-cell type

choroid plexus epithelial cells: 274 nCPM
proximal tubule cells: 273 nCPM
ependymal cells: 226 nCPM
thyrotrophs: 198 nCPM
gonadotrophs: 187 nCPM
lactotrophs: 168 nCPM

Immune cell

MAIT T-cell: 5.1 nTPM
memory CD8 T-cell: 4.7 nTPM
NK-cell: 4.5 nTPM
gdT-cell: 4.2 nTPM
memory CD4 T-cell: 3.2 nTPM
naive CD8 T-cell: 2.9 nTPM

Brain region

choroid plexus: 29 nTPM
medulla oblongata: 21 nTPM
pons: 21 nTPM
midbrain: 20 nTPM
hypothalamus: 19 nTPM
white matter: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.53
gnomAD pLI: 0
gnomAD missense Z: 1.85
DepMap mean gene effect: 0.14
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

GTPase activator activity

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

GTPase activation

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TBC1D19 as an antibody target. Whether an autoantibody or antibody against TBC1D19 could matter depends on whether native TBC1D19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TBC1D19 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TBC1D19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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