Seroatlas · Human Serome Atlas

TBC1D17

TBC1 domain family member 17

Also known as: FLJ12168, TBC17_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HA65
Gene: TBC1D17
Ensembl: ENSG00000104946
Chromosome: 19
Canonical length: 648 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable GTPase activator activity. Involved in retrograde transport, endosome to Golgi. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

648 residues, UniProt reviewed canonical sequence.

>Q9HA65|TBC1D17
     1  MEGAGYRVVF EKGGVYLHTS AKKYQDRDSL IAGVIRVVEK DNDVLLHWAP VEEAGDSTQI
    61  LFSKKDSSGG DSCASEEEPT FDPGYEPDWA VISTVRPQLC HSEPTRGAEP SCPQGSWAFS
   121  VSLGELKSIR RSKPGLSWAY LVLVTQAGGS LPALHFHRGG TRALLRVLSR YLLLASSPQD
   181  SRLYLVFPHD SSALSNSFHH LQLFDQDSSN VVSRFLQDPY STTFSSFSRV TNFFRGALQP
   241  QPEGAASDLP PPPDDEPEPG FEVISCVELG PRPTVERGPP VTEEEWARHV GPEGRLQQVP
   301  ELKNRIFSGG LSPSLRREAW KFLLGYLSWE GTAEEHKAHI RKKTDEYFRM KLQWKSVSPE
   361  QERRNSLLHG YRSLIERDVS RTDRTNKFYE GPENPGLGLL NDILLTYCMY HFDLGYVQGM
   421  SDLLSPILYV IQNEVDAFWC FCGFMELVQG NFEESQETMK RQLGRLLLLL RVLDPLLCDF
   481  LDSQDSGSLC FCFRWLLIWF KREFPFPDVL RLWEVLWTGL PGPNLHLLVA CAILDMERDT
   541  LMLSGFGSNE ILKHINELTM KLSVEDVLTR AEALHRQLTA CPELPHNVQE ILGLAPPAEP
   601  HSPSPTASPL PLSPTRAPPT PPPSTDTAPQ PDSSLEILPE EEDEGADS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TBC1D17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 132 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 132 nTPM
cerebral cortex: 49 nTPM
skin: 45 nTPM
blood vessel: 44 nTPM
spinal cord: 42 nTPM
basal ganglia: 40 nTPM

Single-cell type

oocytes: 341 nCPM
syncytiotrophoblasts: 89 nCPM
cytotrophoblasts: 60 nCPM
innate lymphoid cells: 59 nCPM
rod photoreceptor cells: 43 nCPM
retinal horizontal cells: 42 nCPM

Immune cell

basophil: 14 nTPM
naive B-cell: 11 nTPM
NK-cell: 11 nTPM
eosinophil: 8.5 nTPM
memory CD8 T-cell: 8.3 nTPM
memory B-cell: 8.1 nTPM

Brain region

white matter: 78 nTPM
medulla oblongata: 77 nTPM
basal ganglia: 67 nTPM
pons: 67 nTPM
cerebellum: 64 nTPM
cerebral cortex: 63 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.21
gnomAD pLI: 0
gnomAD missense Z: 0.15
DepMap mean gene effect: -0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

GTPase activator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TBC1D17 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

OPTN

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TBC1D17 as an antibody target. Whether an autoantibody or antibody against TBC1D17 could matter depends on whether native TBC1D17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TBC1D17 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TBC1D17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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