Seroatlas · Human Serome Atlas

TBC1D16

TBC1 domain family member 16

Also known as: FLJ20748, MGC25062, TBC16_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TBP0
Gene: TBC1D16
Ensembl: ENSG00000167291
Chromosome: 17
Canonical length: 767 aa
Protein class: Predicted intracellular proteins
Subcellular location: Intermediate filaments

OverviewNCBI Gene

Enables GTPase activator activity. Involved in regulation of receptor recycling. Located in cytosol and early endosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

767 residues, UniProt reviewed canonical sequence.

>Q8TBP0|TBC1D16
     1  MSLGRLLRRA SSKASDLLTL TPGGSGSGSP SVLDGEIIYS KNNVCVHPPE GLQGLGEHHP
    61  GYLCLYMEKD EMLGATLILA WVPNSRIQRQ DEEALRYITP ESSPVRKAPR PRGRRTRSSG
   121  ASHQPSPTEL RPTLTPKDED ILVVAQSVPD RMLASPAPED EEKLAQGLGV DGAQPASQPA
   181  CSPSGILSTV SPQDVTEEGR EPRPEAGEED GSLELSAEGV SRDSSFDSDS DTFSSPFCLS
   241  PISAALAESR GSVFLESDSS PPSSSDAGLR FPDSNGLLQT PRWDEPQRVC ALEQICGVFR
   301  VDLGHMRSLR LFFSDEACTS GQLVVASRES QYKVFHFHHG GLDKLSDVFQ QWKYCTEMQL
   361  KDQQVAPDKT CMQFSIRRPK LPSSETHPEE SMYKRLGVSA WLNHLNELGQ VEEEYKLRKA
   421  IFFGGIDVSI RGEVWPFLLR YYSHESTSEE REALRLQKRK EYSEIQQKRL SMTPEEHRAF
   481  WRNVQFTVDK DVVRTDRNNQ FFRGEDNPNV ESMRRILLNY AVYNPAVGYS QGMSDLVAPI
   541  LAEVLDESDT FWCFVGLMQN TIFVSSPRDE DMEKQLLYLR ELLRLTHVRF YQHLVSLGED
   601  GLQMLFCHRW LLLCFKREFP EAEALRIWEA CWAHYQTDYF HLFICVAIVA IYGDDVIEQQ
   661  LATDQMLLHF GNLAMHMNGE LVLRKARSLL YQFRLLPRIP CSLHDLCKLC GSGMWDSGSM
   721  PAVECTGHHP GSESCPYGGT VEMPSPKSLR EGKKGPKTPQ DGFGFRR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TBC1D16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 35 nTPM
kidney: 31 nTPM
salivary gland: 28 nTPM
cerebellum: 23 nTPM
breast: 18 nTPM
basal ganglia: 17 nTPM

Single-cell type

retinal horizontal cells: 337 nCPM
kupffer cells: 263 nCPM
melanocytes: 190 nCPM
fibro-adipogenic progenitors: 135 nCPM
loop of henle epithelial cells: 132 nCPM
epididymal principal cells: 120 nCPM

Immune cell

non-classical monocyte: 2.3 nTPM
intermediate monocyte: 1.9 nTPM
naive B-cell: 0.5 nTPM
MAIT T-cell: 0.2 nTPM
total PBMC: 0.2 nTPM
classical monocyte: 0.1 nTPM

Brain region

thalamus: 89 nTPM
basal ganglia: 59 nTPM
cerebellum: 59 nTPM
midbrain: 57 nTPM
medulla oblongata: 46 nTPM
amygdala: 45 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.77
gnomAD pLI: 0
gnomAD missense Z: 0.56
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of receptor recycling

Molecular functions

GTPase activator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

GTPase activation

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TBC1D16 as an antibody target. Whether an autoantibody or antibody against TBC1D16 could matter depends on whether native TBC1D16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TBC1D16 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TBC1D16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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