TAS2R8
Taste receptor type 2 member 8
Also known as: T2R8, TA2R8_HUMAN, TRB5
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9NYW2
- Gene
- TAS2R8
- Ensembl
- ENSG00000121314
- Chromosome
- 12
- Canonical length
- 309 aa
- Protein class
- G-protein coupled receptors, Predicted membrane proteins
OverviewNCBI Gene
This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
309 residues, UniProt reviewed canonical sequence.
>Q9NYW2|TAS2R8
1 MFSPADNIFI ILITGEFILG ILGNGYIALV NWIDWIKKKK ISTVDYILTN LVIARICLIS
61 VMVVNGIVIV LNPDVYTKNK QQIVIFTFWT FANYLNMWIT TCLNVFYFLK IASSSHPLFL
121 WLKWKIDMVV HWILLGCFAI SLLVSLIAAI VLSCDYRFHA IAKHKRNITE MFHVSKIPYF
181 EPLTLFNLFA IVPFIVSLIS FFLLVRSLWR HTKQIKLYAT GSRDPSTEVH VRAIKTMTSF
241 IFFFFLYYIS SILMTFSYLM TKYKLAVEFG EIAAILYPLG HSLILIVLNN KLRQTFVRML
301 TCRKIACMILocalizationUniProt · AlphaFold · HPA
Whether an antibody against TAS2R8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 7
- Mean surface accessibility (rSASA)
- 0.31
- Highest tissue expression
- 0 nTPM
Expression across tissuesHPA
Tissue
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
- basal ganglia: 0 nTPM
- blood vessel: 0 nTPM
Single-cell type
- brain inhibitory neurons: 0.4 nCPM
- brain excitatory neurons: 0.3 nCPM
- oligodendrocyte progenitor cells: 0.2 nCPM
- oligodendrocytes: 0.2 nCPM
- other brain neurons: 0.2 nCPM
- astrocytes: 0.1 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 0.6 nTPM
- medulla oblongata: 0.6 nTPM
- white matter: 0.6 nTPM
- hypothalamus: 0.5 nTPM
- pons: 0.5 nTPM
- hippocampal formation: 0.3 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD missense Z
- -1.16
- DepMap mean gene effect
- 0.1
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TAS2R8 as an antibody target. Whether an autoantibody or antibody against TAS2R8 could matter depends on whether native TAS2R8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TAS2R8 is annotated at the cell surface, where native TAS2R8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label TAS2R8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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