Seroatlas · Human Serome Atlas

TAS2R60

Taste receptor type 2 member 60

Also known as: T2R60, T2R60_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P59551
Gene: TAS2R60
Ensembl: ENSG00000185899
Chromosome: 7
Canonical length: 318 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of the bitter taste receptor family which belong to the G protein-coupled receptor superfamily and are predominantly expressed in taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a seven-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered together with eight other taste receptor genes on chromosome 7. [provided by RefSeq, Jul 2017]

Canonical amino-acid sequenceUniProt

318 residues, UniProt reviewed canonical sequence.

>P59551|TAS2R60
     1  MNGDHMVLGS SVTDKKAIIL VTILLLLRLV AIAGNGFITA ALGVEWVLRR MLLPCDKLLV
    61  SLGASRFCLQ SVVMGKTIYV FLHPMAFPYN PVLQFLAFQW DFLNAATLWS STWLSVFYCV
   121  KIATFTHPVF FWLKHKLSGW LPWMLFSSVG LSSFTTILFF IGNHRMYQNY LRNHLQPWNV
   181  TGDSIRSYCE KFYLFPLKMI TWTMPTAVFF ICMILLITSL GRHRKKALLT TSGFREPSVQ
   241  AHIKALLALL SFAMLFISYF LSLVFSAAGI FPPLDFKFWV WESVIYLCAA VHPIILLFSN
   301  CRLRAVLKSR RSSRCGTP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAS2R60 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 0.1 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 0.1 nTPM
liver: 0.1 nTPM
pancreas: 0.1 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
astrocytes: 0 nCPM

Immune cell

classical monocyte: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM
naive CD4 T-cell: 0.1 nTPM
neutrophil: 0.1 nTPM
non-classical monocyte: 0.1 nTPM
basophil: 0 nTPM

Brain region

cerebellum: 0.4 nTPM
cerebral cortex: 0.3 nTPM
hypothalamus: 0.1 nTPM
medulla oblongata: 0.1 nTPM
midbrain: 0.1 nTPM
pons: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: 0.82
DepMap mean gene effect: 0.14
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

sensory perception of bitter taste

Molecular functions

G protein-coupled receptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TAS2R60 as an antibody target. Whether an autoantibody or antibody against TAS2R60 could matter depends on whether native TAS2R60 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TAS2R60 is annotated at the cell surface, where native TAS2R60 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TAS2R60 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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