TAS2R5
Taste receptor type 2 member 5
Also known as: T2R5, TA2R5_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9NYW4
- Gene
- TAS2R5
- Ensembl
- ENSG00000127366
- Chromosome
- 7
- Canonical length
- 299 aa
- Protein class
- G-protein coupled receptors, Predicted membrane proteins
- Subcellular location
- Nucleoplasm,Nucleoli,Cytoplasmic bodies
OverviewNCBI Gene
This gene encodes a bitter taste receptor; bitter taste receptors are members of the G protein-coupled receptor superfamily and are specifically expressed by taste receptor cells of the tongue and palate epithelia. Each of these apparently intronless taste receptor genes encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes on chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
299 residues, UniProt reviewed canonical sequence.
>Q9NYW4|TAS2R5
1 MLSAGLGLLM LVAVVEFLIG LIGNGSLVVW SFREWIRKFN WSSYNLIILG LAGCRFLLQW
61 LIILDLSLFP LFQSSRWLRY LSIFWVLVSQ ASLWFATFLS VFYCKKITTF DRPAYLWLKQ
121 RAYNLSLWCL LGYFIINLLL TVQIGLTFYH PPQGNSSIRY PFESWQYLYA FQLNSGSYLP
181 LVVFLVSSGM LIVSLYTHHK KMKVHSAGRR DVRAKAHITA LKSLGCFLLL HLVYIMASPF
241 SITSKTYPPD LTSVFIWETL MAAYPSLHSL ILIMGIPRVK QTCQKILWKT VCARRCWGPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TAS2R5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 7
- Mean surface accessibility (rSASA)
- 0.31
- Highest tissue expression
- 4 nTPM
Expression across tissuesHPA
Tissue
- skin: 4 nTPM
- cerebellum: 3.7 nTPM
- ovary: 3.6 nTPM
- cervix: 2.8 nTPM
- fallopian tube: 2.8 nTPM
- epididymis: 2.6 nTPM
Single-cell type
- epicardial cells: 2.3 nCPM
- bergmann glia: 1 nCPM
- kupffer cells: 1 nCPM
- thymocytes: 0.8 nCPM
- distal convoluted tubule cells: 0.7 nCPM
- gonadotrophs: 0.7 nCPM
Immune cell
- T-reg: 0.2 nTPM
- gdT-cell: 0.1 nTPM
- memory B-cell: 0.1 nTPM
- naive B-cell: 0.1 nTPM
- naive CD4 T-cell: 0.1 nTPM
- naive CD8 T-cell: 0.1 nTPM
Brain region
- cerebellum: 8.2 nTPM
- white matter: 7 nTPM
- hypothalamus: 6.6 nTPM
- midbrain: 6.5 nTPM
- basal ganglia: 6.2 nTPM
- cerebral cortex: 6.2 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.53
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.08
- DepMap mean gene effect
- -0.01
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TAS2R5 as an antibody target. Whether an autoantibody or antibody against TAS2R5 could matter depends on whether native TAS2R5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TAS2R5 is annotated at the cell surface, where native TAS2R5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label TAS2R5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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