TAS2R46
Taste receptor type 2 member 46
Also known as: T2R46_HUMAN, T2R54
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P59540
- Gene
- TAS2R46
- Ensembl
- ENSG00000226761
- Chromosome
- 12
- Canonical length
- 309 aa
- Protein class
- G-protein coupled receptors, Predicted membrane proteins, Transporters
OverviewNCBI Gene
TAS2R46 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). For further information on TAS2Rs, see MIM 604791.[supplied by OMIM, Sep 2009]
Canonical amino-acid sequenceUniProt
309 residues, UniProt reviewed canonical sequence.
>P59540|TAS2R46
1 MITFLPIIFS ILIVVTFVIG NFANGFIALV NSIEWFKRQK ISFADQILTA LAVSRVGLLW
61 VLVLNWYATE LNPAFNSIEV RITAYNVWAV INHFSNWLAT SLSIFYLLKI ANFSNLIFLH
121 LKRRVKSVVL VILLGPLLFL VCHLFVINMN QIIWTKEYEG NMTWKIKLRS AMYLSNTTVT
181 ILANLVPFTL TLISFLLLIC SLCKHLKKMQ LHGKGSQDPS MKVHIKALQT VTSFLLLCAI
241 YFLSIIMSVW SFESLENKPV FMFCEAIAFS YPSTHPFILI WGNKKLKQTF LSVLWHVRYW
301 VKGEKPSSSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TAS2R46 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 7
- Mean surface accessibility (rSASA)
- 0.31
- Highest tissue expression
- 0.2 nTPM
Expression across tissuesHPA
Tissue
- cerebellum: 0.2 nTPM
- cervix: 0.1 nTPM
- ovary: 0.1 nTPM
- pituitary gland: 0.1 nTPM
- testis: 0.1 nTPM
- adipose tissue: 0 nTPM
Single-cell type
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
- alveolar cells type 2: 0 nCPM
- astrocytes: 0 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebellum: 1.2 nTPM
- white matter: 1.2 nTPM
- hypothalamus: 1.1 nTPM
- pons: 1 nTPM
- basal ganglia: 0.9 nTPM
- cerebral cortex: 0.9 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about TAS2R46.
Disease | ImmuneIEDB
Conditions an epitope on TAS2R46 was assayed in.
- lung adenocarcinoma T cell
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD missense Z
- -0.96
- DepMap mean gene effect
- -0.11
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TAS2R46 as an antibody target. Whether an autoantibody or antibody against TAS2R46 could matter depends on whether native TAS2R46 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TAS2R46 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label TAS2R46 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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