Seroatlas · Human Serome Atlas

TAS2R45

Taste receptor type 2 member 45

Also known as: T2R45_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P59539
Gene: TAS2R45
Canonical length: 299 aa

OverviewNCBI Gene

No narrative summary is available for TAS2R45 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

299 residues, UniProt reviewed canonical sequence.

>P59539|TAS2R45
     1  MITFLPIIFS ILVVVTFVIG NFANGFIALV NSTEWVKRQK ISFADQIVTA LAVSRVGLLW
    61  VLLLNWYSTV LNPAFCSVEL RTTAYNIWAV TGHFSNWPAT SLSIFYLLKI ANFSNLIFLR
   121  LKRRVKSVIL VVLLGPLLFL ACHLFVVNMN QIVWTKEYEG NMTWKIKLRR AMYLSDTTVT
   181  MLANLVPFTV TLISFLLLVC SLCKHLKKMQ LHGKGSQDPS TKVHIKVLQT VISFFLLRAI
   241  YFVSVIISVW SFKNLENKPV FMFCQAIGFS CSSAHPFILI WGNKKLKQTY LSVLWQMRY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAS2R45 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.3

OntologyGO

Biological processes

sensory perception of taste

Molecular functions

G protein-coupled receptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TAS2R45 as an antibody target. Whether an autoantibody or antibody against TAS2R45 could matter depends on whether native TAS2R45 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TAS2R45 is annotated at the cell surface, where native TAS2R45 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TAS2R45 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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