Seroatlas · Human Serome Atlas

TAS2R43

Taste receptor type 2 member 43

Also known as: T2R43_HUMAN, T2R52

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P59537
Gene: TAS2R43
Ensembl: ENSG00000255374
Chromosome: 12
Canonical length: 309 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

TAS2R43 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). For further information on TAS2Rs, see MIM 604791.[supplied by OMIM, Mar 2009]

Canonical amino-acid sequenceUniProt

309 residues, UniProt reviewed canonical sequence.

>P59537|TAS2R43
     1  MITFLPIIFS SLVVVTFVIG NFANGFIALV NSIEWFKRQK ISFADQILTA LAVSRVGLLW
    61  VLLLNWYSTV LNPAFNSVEV RTTAYNIWAV INHFSNWLAT TLSIFYLLKI ANFSNFIFLH
   121  LKRRVKSVIL VMLLGPLLFL ACHLFVINMN EIVRTKEFEG NMTWKIKLKS AMYFSNMTVT
   181  MVANLVPFTL TLLSFMLLIC SLCKHLKKMQ LHGKGSQDPS TKVHIKALQT VISFLLLCAI
   241  YFLSIMISVW SFGSLENKPV FMFCKAIRFS YPSIHPFILI WGNKKLKQTF LSVFWQMRYW
   301  VKGEKTSSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAS2R43 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 0.2 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 0.2 nTPM
ovary: 0.2 nTPM
cervix: 0.1 nTPM
colon: 0.1 nTPM
endometrium: 0.1 nTPM
pancreas: 0.1 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
astrocytes: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 1 nTPM
choroid plexus: 0.9 nTPM
cerebral cortex: 0.8 nTPM
thalamus: 0.8 nTPM
hypothalamus: 0.7 nTPM
medulla oblongata: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -0.85
DepMap mean gene effect: 0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TAS2R43 as an antibody target. Whether an autoantibody or antibody against TAS2R43 could matter depends on whether native TAS2R43 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TAS2R43 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TAS2R43 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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