TAS2R40
Taste receptor type 2 member 40
Also known as: GPR60, T2R40_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P59535
- Gene
- TAS2R40
- Ensembl
- ENSG00000221937
- Chromosome
- 7
- Canonical length
- 323 aa
- Protein class
- G-protein coupled receptors, Predicted membrane proteins
OverviewNCBI Gene
This gene encodes a member of the bitter taste receptor family which belong to the G protein-coupled receptor superfamily and are predominantly expressed in taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a seven-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered together with eight other taste receptor genes on chromosome 7. A decrease in the expression of this gene is associated with hypogeusia. [provided by RefSeq, Jul 2017]
Canonical amino-acid sequenceUniProt
323 residues, UniProt reviewed canonical sequence.
>P59535|TAS2R40
1 MATVNTDATD KDISKFKVTF TLVVSGIECI TGILGSGFIT AIYGAEWARG KTLPTGDRIM
61 LMLSFSRLLL QIWMMLENIF SLLFRIVYNQ NSVYILFKVI TVFLNHSNLW FAAWLKVFYC
121 LRIANFNHPL FFLMKRKIIV LMPWLLRLSV LVSLSFSFPL SRDVFNVYVN SSIPIPSSNS
181 TEKKYFSETN MVNLVFFYNM GIFVPLIMFI LAATLLILSL KRHTLHMGSN ATGSRDPSMK
241 AHIGAIKATS YFLILYIFNA IALFLSTSNI FDTYSSWNIL CKIIMAAYPA GHSVQLILGN
301 PGLRRAWKRF QHQVPLYLKG QTLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TAS2R40 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 7
- Mean surface accessibility (rSASA)
- 0.31
- Highest tissue expression
- 0.7 nTPM
Expression across tissuesHPA
Tissue
- spleen: 0.7 nTPM
- appendix: 0.6 nTPM
- lung: 0.1 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
Single-cell type
- oligodendrocytes: 0.3 nCPM
- retinal bipolar cells: 0.2 nCPM
- cardiomyocytes: 0.1 nCPM
- macrophages: 0.1 nCPM
- neutrophils: 0.1 nCPM
- schwann cells: 0.1 nCPM
Immune cell
- neutrophil: 2.8 nTPM
- gdT-cell: 0.2 nTPM
- classical monocyte: 0.1 nTPM
- basophil: 0 nTPM
- eosinophil: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- white matter: 26 nTPM
- medulla oblongata: 19 nTPM
- pons: 14 nTPM
- basal ganglia: 13 nTPM
- thalamus: 12 nTPM
- cerebral cortex: 12 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.31
- gnomAD pLI
- 0.03
- gnomAD missense Z
- 0.23
- DepMap mean gene effect
- 0.05
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TAS2R40 as an antibody target. Whether an autoantibody or antibody against TAS2R40 could matter depends on whether native TAS2R40 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TAS2R40 is annotated at the cell surface, where native TAS2R40 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label TAS2R40 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...