Seroatlas · Human Serome Atlas

TAS2R4

Taste receptor type 2 member 4

Also known as: T2R4, TA2R4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NYW5
Gene: TAS2R4
Ensembl: ENSG00000127364
Chromosome: 7
Canonical length: 299 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

299 residues, UniProt reviewed canonical sequence.

>Q9NYW5|TAS2R4
     1  MLRLFYFSAI IASVILNFVG IIMNLFITVV NCKTWVKSHR ISSSDRILFS LGITRFLMLG
    61  LFLVNTIYFV SSNTERSVYL SAFFVLCFMF LDSSSVWFVT LLNILYCVKI TNFQHSVFLL
   121  LKRNISPKIP RLLLACVLIS AFTTCLYITL SQASPFPELV TTRNNTSFNI SEGILSLVVS
   181  LVLSSSLQFI INVTSASLLI HSLRRHIQKM QKNATGFWNP QTEAHVGAMK LMVYFLILYI
   241  PYSVATLVQY LPFYAGMDMG TKSICLIFAT LYSPGHSVLI IITHPKLKTT AKKILCFKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAS2R4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 3.1 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 3.1 nTPM
basal ganglia: 1.5 nTPM
retina: 1 nTPM
cerebral cortex: 0.9 nTPM
epididymis: 0.9 nTPM
ovary: 0.9 nTPM

Single-cell type

lactotrophs: 0.1 nCPM
somatotrophs: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM

Immune cell

basophil: 0.3 nTPM
eosinophil: 0.1 nTPM
neutrophil: 0.1 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebellum: 9.5 nTPM
hypothalamus: 6.9 nTPM
basal ganglia: 6.8 nTPM
midbrain: 6.8 nTPM
cerebral cortex: 6.6 nTPM
white matter: 6.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.91
gnomAD pLI: 0
gnomAD missense Z: -0.09
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TAS2R4 as an antibody target. Whether an autoantibody or antibody against TAS2R4 could matter depends on whether native TAS2R4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TAS2R4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TAS2R4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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