TAS2R39
Taste receptor type 2 member 39
Also known as: T2R39_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P59534
- Gene
- TAS2R39
- Ensembl
- ENSG00000236398
- Chromosome
- 7
- Canonical length
- 338 aa
- Protein class
- G-protein coupled receptors, Predicted membrane proteins
OverviewNCBI Gene
The protein encoded by this gene is a bitter taste receptor that detects green tea catechins, soy isoflavones, and theaflavins. The encoded protein is gustducin-linked and may activate alpha gustducin. This gene is intronless. [provided by RefSeq, Dec 2015]
Canonical amino-acid sequenceUniProt
338 residues, UniProt reviewed canonical sequence.
>P59534|TAS2R39
1 MLGRCFPPDT KEKQQLRMTK LCDPAESELS PFLITLILAV LLAEYLIGII ANGFIMAIHA
61 AEWVQNKAVS TSGRILVFLS VSRIALQSLM MLEITISSTS LSFYSEDAVY YAFKISFIFL
121 NFCSLWFAAW LSFFYFVKIA NFSYPLFLKL RWRITGLIPW LLWLSVFISF SHSMFCINIC
181 TVYCNNSFPI HSSNSTKKTY LSEINVVGLA FFFNLGIVTP LIMFILTATL LILSLKRHTL
241 HMGSNATGSN DPSMEAHMGA IKAISYFLIL YIFNAVALFI YLSNMFDINS LWNNLCQIIM
301 AAYPASHSIL LIQDNPGLRR AWKRLQLRLH LYPKEWTLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TAS2R39 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 7
- Mean surface accessibility (rSASA)
- 0.33
- Highest tissue expression
- 0 nTPM
Expression across tissuesHPA
Tissue
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
- basal ganglia: 0 nTPM
- blood vessel: 0 nTPM
Single-cell type
- oligodendrocytes: 0.5 nCPM
- cardiomyocytes: 0.3 nCPM
- early spermatids: 0.2 nCPM
- b-cells: 0.1 nCPM
- neutrophils: 0.1 nCPM
- vascular smooth muscle cells: 0.1 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- white matter: 20 nTPM
- medulla oblongata: 17 nTPM
- pons: 12 nTPM
- basal ganglia: 11 nTPM
- midbrain: 10 nTPM
- thalamus: 10 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.93
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.14
- DepMap mean gene effect
- -0.03
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TAS2R39 as an antibody target. Whether an autoantibody or antibody against TAS2R39 could matter depends on whether native TAS2R39 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TAS2R39 is annotated at the cell surface, where native TAS2R39 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label TAS2R39 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...