TAS2R38

Protein identityUniProt · HPA

UniProt accession

P59533

Gene

TAS2R38

Ensembl

ENSG00000257138

Chromosome

7

Canonical length

333 aa

Protein class

G-protein coupled receptors, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a seven-transmembrane G protein-coupled receptor that controls the ability to taste glucosinolates, a family of bitter-tasting compounds found in plants of the Brassica sp. Synthetic compounds phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) have been identified as ligands for this receptor and have been used to test the genetic diversity of this gene. Although several allelic forms of this gene have been identified worldwide, there are two predominant common forms (taster and non-taster) found outside of Africa. These alleles differ at three nucleotide positions resulting in amino acid changes in the protein (A49P, A262V, and V296I) with the amino acid combination PAV identifying the taster variant (and AVI identifying the non-taster variant). [provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

333 residues, UniProt reviewed canonical sequence.

>P59533|TAS2R38
     1  MLTLTRIRTV SYEVRSTFLF ISVLEFAVGF LTNAFVFLVN FWDVVKRQAL SNSDCVLLCL
    61  SISRLFLHGL LFLSAIQLTH FQKLSEPLNH SYQAIIMLWM IANQANLWLA ACLSLLYCSK
   121  LIRFSHTFLI CLASWVSRKI SQMLLGIILC SCICTVLCVW CFFSRPHFTV TTVLFMNNNT
   181  RLNWQIKDLN LFYSFLFCYL WSVPPFLLFL VSSGMLTVSL GRHMRTMKVY TRNSRDPSLE
   241  AHIKALKSLV SFFCFFVISS CAAFISVPLL ILWRDKIGVM VCVGIMAACP SGHAAILISG
   301  NAKLRRAVMT ILLWAQSSLK VRADHKADSR TLC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAS2R38 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

7

Mean surface accessibility (rSASA)

0.32

Highest tissue expression

0.3 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.13

gnomAD pLI

0.13

gnomAD missense Z

0.73

DepMap mean gene effect

0

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• detection of chemical stimulus involved in sensory perception of bitter taste

Molecular functions

• bitter taste receptor activity
• G protein-coupled receptor activity

Cellular components

• membrane
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Taste receptor type 2
• Taste receptor protein (TAS2R)
• Taste receptor type 2 member 38

KeywordsUniProt

• G-protein coupled receptor
• Glycoprotein
• Membrane
• Receptor
• Sensory transduction
• Taste
• Transducer
• Transmembrane
• Transmembrane helix