Seroatlas · Human Serome Atlas

TAS2R31

Taste receptor type 2 member 31

Also known as: T2R31, T2R31_HUMAN, T2R53, TAS2R44

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P59538
Gene: TAS2R31
Ensembl: ENSG00000256436
Chromosome: 12
Canonical length: 309 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

TAS2R44 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). For further information on TAS2Rs, see MIM 604791.[supplied by OMIM, Mar 2009]

Canonical amino-acid sequenceUniProt

309 residues, UniProt reviewed canonical sequence.

>P59538|TAS2R31
     1  MTTFIPIIFS SVVVVLFVIG NFANGFIALV NSIERVKRQK ISFADQILTA LAVSRVGLLW
    61  VLLLNWYSTV FNPAFYSVEV RTTAYNVWAV TGHFSNWLAT SLSIFYLLKI ANFSNLIFLH
   121  LKRRVKSVIL VMLLGPLLFL ACQLFVINMK EIVRTKEYEG NLTWKIKLRS AVYLSDATVT
   181  TLGNLVPFTL TLLCFLLLIC SLCKHLKKMQ LHGKGSQDPS TKVHIKALQT VIFFLLLCAV
   241  YFLSIMISVW SFGSLENKPV FMFCKAIRFS YPSIHPFILI WGNKKLKQTF LSVLRQVRYW
   301  VKGEKPSSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAS2R31 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 0.9 nTPM

Expression across tissuesHPA

Tissue

ovary: 0.9 nTPM
testis: 0.7 nTPM
pituitary gland: 0.6 nTPM
cerebellum: 0.5 nTPM
endometrium: 0.5 nTPM
cervix: 0.4 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
astrocytes: 0 nCPM

Immune cell

plasmacytoid DC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

hypothalamus: 2.6 nTPM
white matter: 2.3 nTPM
cerebellum: 1.8 nTPM
cerebral cortex: 1.8 nTPM
medulla oblongata: 1.7 nTPM
pons: 1.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -1.56
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

detection of chemical stimulus involved in sensory perception of bitter taste

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TAS2R31 as an antibody target. Whether an autoantibody or antibody against TAS2R31 could matter depends on whether native TAS2R31 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TAS2R31 is annotated at the cell surface, where native TAS2R31 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TAS2R31 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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