Seroatlas · Human Serome Atlas

TAS2R30

Taste receptor type 2 member 30

Also known as: T2R30, T2R30_HUMAN, TAS2R47

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P59541
Gene: TAS2R30
Ensembl: ENSG00000256188
Chromosome: 12
Canonical length: 319 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

Enables bitter taste receptor activity. Involved in detection of chemical stimulus involved in sensory perception of bitter taste. Predicted to be located in plasma membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

319 residues, UniProt reviewed canonical sequence.

>P59541|TAS2R30
     1  MITFLPIIFS ILIVVIFVIG NFANGFIALV NSIEWVKRQK ISFVDQILTA LAVSRVGLLW
    61  VLLLHWYATQ LNPAFYSVEV RITAYNVWAV TNHFSSWLAT SLSMFYLLRI ANFSNLIFLR
   121  IKRRVKSVVL VILLGPLLFL VCHLFVINMD ETVWTKEYEG NVTWKIKLRS AMYHSNMTLT
   181  MLANFVPLTL TLISFLLLIC SLCKHLKKMQ LHGKGSQDPS TKVHIKALQT VTSFLLLCAI
   241  YFLSMIISVC NFGRLEKQPV FMFCQAIIFS YPSTHPFILI LGNKKLKQIF LSVLRHVRYW
   301  VKDRSLRLHR FTRGALCVF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAS2R30 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 0.2 nTPM

Expression across tissuesHPA

Tissue

retina: 0.2 nTPM
bone marrow: 0.1 nTPM
breast: 0.1 nTPM
cerebellum: 0.1 nTPM
endometrium: 0.1 nTPM
ovary: 0.1 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
astrocytes: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 10 nTPM
white matter: 7.8 nTPM
hypothalamus: 7.6 nTPM
cerebral cortex: 6.5 nTPM
pons: 6.4 nTPM
thalamus: 6.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -2.07
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

detection of chemical stimulus involved in sensory perception of bitter taste

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TAS2R30 as an antibody target. Whether an autoantibody or antibody against TAS2R30 could matter depends on whether native TAS2R30 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TAS2R30 is annotated at the cell surface, where native TAS2R30 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TAS2R30 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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