Seroatlas · Human Serome Atlas

TAS2R3

Taste receptor type 2 member 3

Also known as: T2R3, TA2R3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NYW6
Gene: TAS2R3
Ensembl: ENSG00000127362
Chromosome: 7
Canonical length: 316 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless taste receptor genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

316 residues, UniProt reviewed canonical sequence.

>Q9NYW6|TAS2R3
     1  MMGLTEGVFL ILSGTQFTLG ILVNCFIELV NGSSWFKTKR MSLSDFIITT LALLRIILLC
    61  IILTDSFLIE FSPNTHDSGI IMQIIDVSWT FTNHLSIWLA TCLGVLYCLK IASFSHPTFL
   121  WLKWRVSRVM VWMLLGALLL SCGSTASLIN EFKLYSVFRG IEATRNVTEH FRKKRSEYYL
   181  IHVLGTLWYL PPLIVSLASY SLLIFSLGRH TRQMLQNGTS SRDPTTEAHK RAIRIILSFF
   241  FLFLLYFLAF LIASFGNFLP KTKMAKMIGE VMTMFYPAGH SFILILGNSK LKQTFVVMLR
   301  CESGHLKPGS KGPIFS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAS2R3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 0.3 nTPM

Expression across tissuesHPA

Tissue

breast: 0.3 nTPM
cerebellum: 0.3 nTPM
retina: 0.3 nTPM
skin: 0.3 nTPM
epididymis: 0.2 nTPM
lymph node: 0.2 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
astrocytes: 0 nCPM

Immune cell

T-reg: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebellum: 14 nTPM
hypothalamus: 12 nTPM
basal ganglia: 11 nTPM
midbrain: 11 nTPM
cerebral cortex: 9.8 nTPM
white matter: 9.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.78
gnomAD pLI: 0
gnomAD missense Z: -0.42
DepMap mean gene effect: 0.22
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

detection of chemical stimulus involved in sensory perception of bitter taste

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TAS2R3 as an antibody target. Whether an autoantibody or antibody against TAS2R3 could matter depends on whether native TAS2R3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TAS2R3 is annotated at the cell surface, where native TAS2R3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TAS2R3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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