Seroatlas · Human Serome Atlas

TAS2R20

Taste receptor type 2 member 20

Also known as: T2R20, T2R20_HUMAN, T2R56, TAS2R49

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P59543
Gene: TAS2R20
Ensembl: ENSG00000255837
Chromosome: 12
Canonical length: 309 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of the taste receptor two family of class C G-protein coupled receptors. Receptors of this family have a short extracellular N-terminus, seven transmembrane helices, three extracellular loops and three intracellular loops, and an intracellular C-terminus. Members of this family are expressed in a subset of taste receptor cells, where they function in bitter taste reception, as well as in non-gustatory cells including those of the brain, reproductive organs, respiratory system, and gastrointestinal system. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

309 residues, UniProt reviewed canonical sequence.

>P59543|TAS2R20
     1  MMSFLHIVFS ILVVVAFILG NFANGFIALI NFIAWVKRQK ISSADQIIAA LAVSRVGLLW
    61  VILLHWYSTV LNPTSSNLKV IIFISNAWAV TNHFSIWLAT SLSIFYLLKI VNFSRLIFHH
   121  LKRKAKSVVL VIVLGSLFFL VCHLVMKHTY INVWTEECEG NVTWKIKLRN AMHLSNLTVA
   181  MLANLIPFTL TLISFLLLIY SLCKHLKKMQ LHGKGSQDPS TKIHIKALQT VTSFLILLAI
   241  YFLCLIISFW NFKMRPKEIV LMLCQAFGII YPSFHSFILI WGNKTLKQTF LSVLWQVTCW
   301  AKGQNQSTP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAS2R20 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 2.6 nTPM

Expression across tissuesHPA

Tissue

ovary: 2.6 nTPM
retina: 2 nTPM
pituitary gland: 1.9 nTPM
cervix: 1.8 nTPM
spleen: 1.8 nTPM
vagina: 1.8 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
astrocytes: 0 nCPM

Immune cell

basophil: 1.2 nTPM
memory B-cell: 0.5 nTPM
myeloid DC: 0.3 nTPM
naive B-cell: 0.3 nTPM
naive CD4 T-cell: 0.3 nTPM
NK-cell: 0.3 nTPM

Brain region

white matter: 7 nTPM
cerebellum: 6.8 nTPM
pons: 6.1 nTPM
cerebral cortex: 5.7 nTPM
choroid plexus: 5.7 nTPM
basal ganglia: 5.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -0.52
DepMap mean gene effect: 0.18
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TAS2R20 as an antibody target. Whether an autoantibody or antibody against TAS2R20 could matter depends on whether native TAS2R20 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TAS2R20 is annotated at the cell surface, where native TAS2R20 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TAS2R20 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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