Seroatlas · Human Serome Atlas

TAS2R2

Taste receptor type 2 member 2

Also known as: TA2R2_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q50KZ9
Gene: TAS2R2
Canonical length: 303 aa

OverviewNCBI Gene

No narrative summary is available for TAS2R2 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

303 residues, UniProt reviewed canonical sequence.

>Q50KZ9|TAS2R2
     1  MALSFSAILH IIMMSAEFFT GITVNGFLII VNCNELIKHR KLMPIQILLM CIGMSRFGLQ
    61  MVLMVQSFFS VFFPLLYVKI IYGAAMMFLW MFFSSISLWF ATCLSVFYCL KISGFTQSCF
   121  LWLKFRIPKL IPWLLLGSVL ASVSIASVCI EVDYAKNVEE DALRNTTLKK SKTKIKKISE
   181  VLLVNLALIF PLAIFVMCTS MLLISLYKHT HRMQHGSHGF RNANTEAHIN ALKTVITFFC
   241  FFISYFAAFM TNMTFSLPYR SHQFFMLKDI MAAYPSGHSV IIILSNSKFQ QSFRRILCLK
   301  KKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAS2R2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.29

OntologyGO

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TAS2R2 as an antibody target. Whether an autoantibody or antibody against TAS2R2 could matter depends on whether native TAS2R2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TAS2R2 is annotated at the cell surface, where native TAS2R2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TAS2R2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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