Seroatlas · Human Serome Atlas

TAS2R10

Taste receptor type 2 member 10

Also known as: T2R10, T2R10_HUMAN, TRB2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NYW0
Gene: TAS2R10
Ensembl: ENSG00000121318
Chromosome: 12
Canonical length: 307 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins
Subcellular location: Vesicles,Plasma membrane,Actin filaments

OverviewNCBI Gene

This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

307 residues, UniProt reviewed canonical sequence.

>Q9NYW0|TAS2R10
     1  MLRVVEGIFI FVVVSESVFG VLGNGFIGLV NCIDCAKNKL STIGFILTGL AISRIFLIWI
    61  IITDGFIQIF SPNIYASGNL IEYISYFWVI GNQSSMWFAT SLSIFYFLKI ANFSNYIFLW
   121  LKSRTNMVLP FMIVFLLISS LLNFAYIAKI LNDYKTKNDT VWDLNMYKSE YFIKQILLNL
   181  GVIFFFTLSL ITCIFLIISL WRHNRQMQSN VTGLRDSNTE AHVKAMKVLI SFIILFILYF
   241  IGMAIEISCF TVRENKLLLM FGMTTTAIYP WGHSFILILG NSKLKQASLR VLQQLKCCEK
   301  RKNLRVT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAS2R10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 0.6 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 0.6 nTPM
retina: 0.5 nTPM
breast: 0.4 nTPM
cerebellum: 0.4 nTPM
endometrium: 0.4 nTPM
epididymis: 0.4 nTPM

Single-cell type

adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM
alveolar cells type 1: 0 nCPM
alveolar cells type 2: 0 nCPM
astrocytes: 0 nCPM

Immune cell

T-reg: 0.2 nTPM
memory B-cell: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

cerebral cortex: 2.7 nTPM
basal ganglia: 2.4 nTPM
white matter: 2.4 nTPM
hypothalamus: 2.1 nTPM
pons: 2 nTPM
amygdala: 1.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD missense Z: -0.65
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

detection of chemical stimulus involved in sensory perception of bitter taste

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TAS2R10 as an antibody target. Whether an autoantibody or antibody against TAS2R10 could matter depends on whether native TAS2R10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TAS2R10 is annotated at the cell surface, where native TAS2R10 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TAS2R10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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