TAS2R1
Taste receptor type 2 member 1
Also known as: T2R1, TA2R1_HUMAN, TRB7
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9NYW7
- Gene
- TAS2R1
- Ensembl
- ENSG00000169777
- Chromosome
- 5
- Canonical length
- 299 aa
- Protein class
- G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins
OverviewNCBI Gene
This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is mapped to chromosome 5p15, the location of a genetic locus (PROP) that controls the detection of the bitter compound 6-n-propyl-2-thiouracil. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
299 residues, UniProt reviewed canonical sequence.
>Q9NYW7|TAS2R1
1 MLESHLIIYF LLAVIQFLLG IFTNGIIVVV NGIDLIKHRK MAPLDLLLSC LAVSRIFLQL
61 FIFYVNVIVI FFIEFIMCSA NCAILLFINE LELWLATWLG VFYCAKVASV RHPLFIWLKM
121 RISKLVPWMI LGSLLYVSMI CVFHSKYAGF MVPYFLRKFF SQNATIQKED TLAIQIFSFV
181 AEFSVPLLIF LFAVLLLIFS LGRHTRQMRN TVAGSRVPGR GAPISALLSI LSFLILYFSH
241 CMIKVFLSSL KFHIRRFIFL FFILVIGIYP SGHSLILILG NPKLKQNAKK FLLHSKCCQLocalizationUniProt · AlphaFold · HPA
Whether an antibody against TAS2R1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 7
- Mean surface accessibility (rSASA)
- 0.3
- Highest tissue expression
- 7 nTPM
Expression across tissuesHPA
Tissue
- testis: 7 nTPM
- basal ganglia: 0.4 nTPM
- retina: 0.2 nTPM
- fallopian tube: 0.1 nTPM
- hippocampal formation: 0.1 nTPM
- parathyroid gland: 0.1 nTPM
Single-cell type
- late spermatids: 57 nCPM
- early spermatids: 27 nCPM
- late primary spermatocytes: 1.7 nCPM
- distal convoluted tubule cells: 0.5 nCPM
- renal connecting tubule cells: 0.4 nCPM
- decidual stromal cells: 0.3 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- basal ganglia: 3.9 nTPM
- cerebral cortex: 2.9 nTPM
- thalamus: 1.9 nTPM
- hippocampal formation: 1.6 nTPM
- white matter: 1.5 nTPM
- hypothalamus: 1.4 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD missense Z
- -0.24
- DepMap mean gene effect
- 0.08
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads TAS2R1 as an antibody target. Whether an autoantibody or antibody against TAS2R1 could matter depends on whether native TAS2R1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
TAS2R1 is annotated at the cell surface, where native TAS2R1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label TAS2R1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...