Seroatlas · Human Serome Atlas

TAL2

T-cell acute lymphocytic leukemia protein 2

Also known as: bHLHa19, TAL2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q16559
Gene: TAL2
Ensembl: ENSG00000186051
Chromosome: 9
Canonical length: 108 aa
Protein class: Cancer-related genes, Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors
Subcellular location: Cytosol

OverviewNCBI Gene

This intronless gene encodes a helix-loop-helix protein. Translocations between this gene on chromosome 9 and the T-cell receptor beta-chain locus on chromosome 7 have been associated with activation of the T-cell acute lymphocytic leukemia 2 gene and T-cell acute lymphoblastic leukemia. [provided by RefSeq, Mar 2009]

Canonical amino-acid sequenceUniProt

108 residues, UniProt reviewed canonical sequence.

>Q16559|TAL2
     1  MTRKIFTNTR ERWRQQNVNS AFAKLRKLIP THPPDKKLSK NETLRLAMRY INFLVKVLGE
    61  QSLQQTGVAA QGNILGLFPQ GPHLPGLEDR TLLENYQVPS PGPSHHIP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 13 nTPM
kidney: 2.8 nTPM
tongue: 2.2 nTPM
choroid plexus: 1.3 nTPM
epididymis: 0.6 nTPM
retina: 0.5 nTPM

Single-cell type

müller glia: 3.2 nCPM
myonuclei: 2.8 nCPM
b-cells: 2 nCPM
other brain neurons: 1.3 nCPM
differentiating spermatogonia: 1.2 nCPM
distal convoluted tubule cells: 1.2 nCPM

Immune cell

naive B-cell: 7.3 nTPM
memory B-cell: 6.9 nTPM
plasmacytoid DC: 1.7 nTPM
NK-cell: 0.2 nTPM
total PBMC: 0.1 nTPM
basophil: 0 nTPM

Brain region

choroid plexus: 2.7 nTPM
cerebral cortex: 2.3 nTPM
midbrain: 1.3 nTPM
pons: 1.3 nTPM
white matter: 1.3 nTPM
basal ganglia: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.47
gnomAD pLI: 0.47
gnomAD missense Z: 0.14
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

chromatin

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TAL2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TAL2 as an antibody target. Whether an autoantibody or antibody against TAL2 could matter depends on whether native TAL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TAL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TAL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...