Seroatlas · Human Serome Atlas

TAGAP

T-cell activation Rho GTPase-activating protein

Also known as: ARHGAP47, FLJ32631, IDDM21, TAGAP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N103
Gene
TAGAP
Ensembl
ENSG00000164691
Chromosome
6
Canonical length
731 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes a member of the Rho GTPase-activator protein superfamily. The encoded protein may function as a Rho GTPase-activating protein. Alterations in this gene may be associated with several diseases, including rheumatoid arthritis, celiac disease, and multiple sclerosis. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

731 residues, UniProt reviewed canonical sequence.

>Q8N103|TAGAP
     1  MKLRSSHNAS KTLNANNMET LIECQSEGDI KEHPLLASCE SEDSICQLIE VKKRKKVLSW
    61  PFLMRRLSPA SDFSGALETD LKASLFDQPL SIICGDSDTL PRPIQDILTI LCLKGPSTEG
   121  IFRRAANEKA RKELKEELNS GDAVDLERLP VHLLAVVFKD FLRSIPRKLL SSDLFEEWMG
   181  ALEMQDEEDR IEALKQVADK LPRPNLLLLK HLVYVLHLIS KNSEVNRMDS SNLAICIGPN
   241  MLTLENDQSL SFEAQKDLNN KVKTLVEFLI DNCFEIFGEN IPVHSSITSD DSLEHTDSSD
   301  VSTLQNDSAY DSNDPDVESN SSSGISSPSR QPQVPMATAA GLDSAGPQDA REVSPEPIVS
   361  TVARLKSSLA QPDRRYSEPS MPSSQECLES RVTNQTLTKS EGDFPVPRVG SRLESEEAED
   421  PFPEEVFPAV QGKTKRPVDL KIKNLAPGSV LPRALVLKAF SSSSLDASSD SSPVASPSSP
   481  KRNFFSRHQS FTTKTEKGKP SREIKKHSMS FTFAPHKKVL TKNLSAGSGK SQDFTRDHVP
   541  RGVRKESQLA GRIVQENGCE THNQTARGFC LRPHALSVDD VFQGADWERP GSPPSYEEAM
   601  QGPAARLVAS ESQTVGSMTV GSMRARMLEA HCLLPPLPPA HHVEDSRHRG SKEPLPGHGL
   661  SPLPERWKQS RTVHASGDSL GHVSGPGRPE LLPLRTVSES VQRNKRDCLV RRCSQPVFEA
   721  DQFQYAKESY I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAGAP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.59
Highest tissue expression
139 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 139 nTPM
  • tonsil: 45 nTPM
  • lymph node: 37 nTPM
  • appendix: 27 nTPM
  • smooth muscle: 24 nTPM
  • thymus: 23 nTPM

Single-cell type

  • neutrophils: 837 nCPM
  • neutrophil progenitors: 162 nCPM
  • t-cells: 150 nCPM
  • b-cells: 134 nCPM
  • nk-cells: 125 nCPM
  • plasma cells: 120 nCPM

Immune cell

  • neutrophil: 170 nTPM
  • basophil: 164 nTPM
  • eosinophil: 89 nTPM
  • memory CD4 T-cell: 74 nTPM
  • memory CD8 T-cell: 65 nTPM
  • MAIT T-cell: 63 nTPM

Brain region

  • white matter: 13 nTPM
  • hypothalamus: 11 nTPM
  • choroid plexus: 9.9 nTPM
  • medulla oblongata: 9.4 nTPM
  • spinal cord: 8.4 nTPM
  • thalamus: 8.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.42
gnomAD pLI
0.85
gnomAD missense Z
1.4
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 1% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TAGAP as an antibody target. Whether an autoantibody or antibody against TAGAP could matter depends on whether native TAGAP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TAGAP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TAGAP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TAGAP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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