Seroatlas · Human Serome Atlas

TAF7L

Transcription initiation factor TFIID subunit 7-like

Also known as: CT40, TAF2Q, TAF7L_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5H9L4
Gene: TAF7L
Ensembl: ENSG00000102387
Chromosome: X
Canonical length: 462 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene is similar to a mouse gene that encodes a TATA box binding protein-associated factor, and shows testis-specific expression. The encoded protein could be a spermatogenesis-specific component of the DNA-binding general transcription factor complex TFIID. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]

Canonical amino-acid sequenceUniProt

462 residues, UniProt reviewed canonical sequence.

>Q5H9L4|TAF7L
     1  MECPEGQLPI SSENDSTPTV STSEVTSQQE PQILVDRGSE TTYESSADIA GDEGTQIPAD
    61  EDTQTDADSS AQAAAQAPEN FQEGKDMSES QDEVPDEVEN QFILRLPLEH ACTVRNLARS
   121  QSVKMKDKLK IDLLPDGRHA VVEVEDVPLA AKLVDLPCVI ESLRTLDKKT FYKTADISQM
   181  LVCTADGDIH LSPEEPAAST DPNIVRKKER GREEKCVWKH GITPPLKNVR KKRFRKTQKK
   241  VPDVKEMEKS SFTEYIESPD VENEVKRLLR SDAEAVSTRW EVIAEDGTKE IESQGSIPGF
   301  LISSGMSSHK QGHTSSEYDM LREMFSDSRS NNDDDEDEDD EDEDEDEDED EDEDKEEEEE
   361  DCSEEYLERQ LQAEFIESGQ YRANEGTSSI VMEIQKQIEK KEKKLHKIQN KAQRQKDLIM
   421  KVENLTLKNH FQSVLEQLEL QEKQKNEKLI SLQEQLQRFL KK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAF7L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

testis: 30 nTPM
choroid plexus: 3.8 nTPM
parathyroid gland: 3.7 nTPM
epididymis: 2.3 nTPM
basal ganglia: 1.9 nTPM
seminal vesicle: 1.6 nTPM

Single-cell type

sertoli cells: 256 nCPM
early primary spermatocytes: 46 nCPM
undifferentiated spermatogonia: 28 nCPM
early spermatids: 24 nCPM
late primary spermatocytes: 21 nCPM
differentiating spermatogonia: 20 nCPM

Immune cell

basophil: 0.1 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 4.8 nTPM
hippocampal formation: 4 nTPM
cerebral cortex: 3.8 nTPM
amygdala: 3.4 nTPM
basal ganglia: 2.7 nTPM
hypothalamus: 2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TAF7L.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 93 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Spermatogenic failure, X-linked, 7

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.27
gnomAD pLI: 0.99
gnomAD missense Z: 0.14
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TAF7L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TAF7L as an antibody target. Whether an autoantibody or antibody against TAF7L could matter depends on whether native TAF7L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TAF7L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TAF7L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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