TAF2

Protein identityUniProt · HPA

UniProt accession

Q6P1X5

Gene

TAF2

Ensembl

ENSG00000064313

Chromosome

8

Canonical length

1199 aa

Protein class

Disease related genes, Human disease related genes, Predicted intracellular proteins

OverviewNCBI Gene

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the larger subunits of TFIID that is stably associated with the TFIID complex. It contributes to interactions at and downstream of the transcription initiation site, interactions that help determine transcription complex response to activators. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1199 residues, UniProt reviewed canonical sequence.

>Q6P1X5|TAF2
     1  MPLTGVEPAR MNRKKGDKGF ESPRPYKLTH QVVCINNINF QRKSVVGFVE LTIFPTVANL
    61  NRIKLNSKQC RIYRVRINDL EAAFIYNDPT LEVCHSESKQ RNLNYFSNAY AAAVSAVDPD
   121  AGNGELCIKV PSELWKHVDE LKVLKIHINF SLDQPKGGLH FVVPSVEGSM AERGAHVFSC
   181  GYQNSTRFWF PCVDSYSELC TWKLEFTVDA AMVAVSNGDL VETVYTHDMR KKTFHYMLTI
   241  PTAASNISLA IGPFEILVDP YMHEVTHFCL PQLLPLLKHT TSYLHEVFEF YEEILTCRYP
   301  YSCFKTVFID EAYVEVAAYA SMSIFSTNLL HSAMIIDETP LTRRCLAQSL AQQFFGCFIS
   361  RMSWSDEWVL KGISGYIYGL WMKKTFGVNE YRHWIKEELD KIVAYELKTG GVLLHPIFGG
   421  GKEKDNPASH LHFSIKHPHT LSWEYYSMFQ CKAHLVMRLI ENRISMEFML QVFNKLLSLA
   481  STASSQKFQS HMWSQMLVST SGFLKSISNV SGKDIQPLIK QWVDQSGVVK FYGSFAFNRK
   541  RNVLELEIKQ DYTSPGTQKY VGPLKVTVQE LDGSFNHTLQ IEENSLKHDI PCHSKSRRNK
   601  KKKIPLMNGE EVDMDLSAMD ADSPLLWIRI DPDMSVLRKV EFEQADFMWQ YQLRYERDVV
   661  AQQESILALE KFPTPASRLA LTDILEQEQC FYRVRMSACF CLAKIANSMV STWTGPPAMK
   721  SLFTRMFCCK SCPNIVKTNN FMSFQSYFLQ KTMPVAMALL RDVHNLCPKE VLTFILDLIK
   781  YNDNRKNKFS DNYYRAEMID ALANSVTPAV SVNNEVRTLD NLNPDVRLIL EEITRFLNME
   841  KLLPSYRHTI TVSCLRAIRV LQKNGHVPSD PALFKSYAEY GHFVDIRIAA LEAVVDYTKV
   901  DRSYEELQWL LNMIQNDPVP YVRHKILNML TKNPPFTKNM ESPLCNEALV DQLWKLMNSG
   961  TSHDWRLRCG AVDLYFTLFG LSRPSCLPLP ELGLVLNLKE KKAVLNPTII PESVAGNQEA
  1021  ANNPSSHPQL VGFQNPFSSS QDEEEIDMDT VHDSQAFISH HLNMLERPST PGLSKYRPAS
  1081  SRSALIPQHS AGCDSTPTTK PQWSLELARK GTGKEQAPLE MSMHPAASAP LSVFTKESTA
  1141  SKHSDHHHHH HHEHKKKKKK HKHKHKHKHK HDSKEKDKEP FTFSSPASGR SIRSPSLSD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.3

Highest tissue expression

7.9 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TAF2.

Disease | AllUniProt

Conditions TAF2 is implicated in, by any mechanism.

• Neurodevelopmental disorder with feeding difficulties, thin corpus callosum, and foot deformity (NEDFCF) MIM:615599

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 367 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Microcephaly-thin corpus callosum-intellectual disability syndrome

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.42

gnomAD pLI

0

gnomAD missense Z

2.78

DepMap mean gene effect

-0.81

DepMap dependency class

common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 17% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• G2/M transition of mitotic cell cycle
• mRNA transcription by RNA polymerase II
• positive regulation of DNA-templated transcription
• positive regulation of transcription initiation by RNA polymerase II
• regulation of DNA repair
• regulation of transcription by RNA polymerase II
• RNA polymerase II preinitiation complex assembly
• transcription initiation at RNA polymerase II promoter
• response to paraquat

Molecular functions

• chromatin binding
• RNA polymerase II general transcription initiation factor activity
• transcription cis-regulatory region binding

Cellular components

• nucleoplasm
• nucleus
• transcription factor TFIID complex
• transcription factor TFTC complex

Protein domainsUniProt · Pfam · InterPro

• Armadillo-type fold
• Peptidase M4/M1, CTD superfamily
• Aminopeptidase N-like , N-terminal domain superfamliy
• Transcription initiation factor TFIID subunit 2
• Transcription initiation factor TFIID subunit 2, Ig-like domain
• Transcription initiation factor TFIID subunit 2, TPR repeats
• TAF2 Ig-like domain
• TAF2-like, TPR repeats

KeywordsUniProt

• Intellectual disability
• Nucleus
• Phosphoprotein
• Transcription
• Transcription regulation

InteractionsUniProt · HPA

Protein binding partners of TAF2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TAF2C1