Seroatlas · Human Serome Atlas

TACR3

Neuromedin-K receptor

Also known as: NK3R, NK3R_HUMAN, NKR, TAC3R

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P29371
Gene
TACR3
Ensembl
ENSG00000169836
Chromosome
4
Canonical length
465 aa
Protein class
Disease related genes, G-protein coupled receptors, Human disease related genes, Potential drug targets, Predicted membrane proteins

OverviewNCBI Gene

This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

465 residues, UniProt reviewed canonical sequence.

>P29371|TACR3
     1  MATLPAAETW IDGGGGVGAD AVNLTASLAA GAATGAVETG WLQLLDQAGN LSSSPSALGL
    61  PVASPAPSQP WANLTNQFVQ PSWRIALWSL AYGVVVAVAV LGNLIVIWII LAHKRMRTVT
   121  NYFLVNLAFS DASMAAFNTL VNFIYALHSE WYFGANYCRF QNFFPITAVF ASIYSMTAIA
   181  VDRYMAIIDP LKPRLSATAT KIVIGSIWIL AFLLAFPQCL YSKTKVMPGR TLCFVQWPEG
   241  PKQHFTYHII VIILVYCFPL LIMGITYTIV GITLWGGEIP GDTCDKYHEQ LKAKRKVVKM
   301  MIIVVMTFAI CWLPYHIYFI LTAIYQQLNR WKYIQQVYLA SFWLAMSSTM YNPIIYCCLN
   361  KRFRAGFKRA FRWCPFIKVS SYDELELKTT RFHPNRQSSM YTVTRMESMT VVFDPNDADT
   421  TRSSRKKRAT PRDPSFNGCS RRNSKSASAT SSFISSPYTS VDEYS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TACR3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
2.5 nTPM

Expression across tissuesHPA

Tissue

  • retina: 2.5 nTPM
  • urinary bladder: 1.7 nTPM
  • hypothalamus: 1.2 nTPM
  • amygdala: 0.6 nTPM
  • midbrain: 0.4 nTPM
  • spinal cord: 0.4 nTPM

Single-cell type

  • podocytes: 91 nCPM
  • myosatellite cells: 81 nCPM
  • retinal bipolar cells: 78 nCPM
  • other brain neurons: 26 nCPM
  • thyrotrophs: 19 nCPM
  • oligodendrocytes: 13 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • pons: 18 nTPM
  • amygdala: 6 nTPM
  • hypothalamus: 5.5 nTPM
  • spinal cord: 4 nTPM
  • midbrain: 3.4 nTPM
  • medulla oblongata: 3.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TACR3.

Disease | AllUniProt

Conditions TACR3 is implicated in, by any mechanism.

  • Hypogonadotropic hypogonadism 11 with or without anosmia (HH11) MIM:614840

Disease | GeneticClinVar

18 pathogenic / likely-pathogenic of 180 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.74
gnomAD pLI
0
gnomAD missense Z
0.58
DepMap mean gene effect
-0.09
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TACR3 as an antibody target. Whether an autoantibody or antibody against TACR3 could matter depends on whether native TACR3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TACR3 is annotated at the cell surface, where native TACR3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TACR3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TACR3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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