Seroatlas · Human Serome Atlas

TACR2

Substance-K receptor

Also known as: NK2R, NK2R_HUMAN, NKNAR, SKR, TAC2R

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P21452
Gene
TACR2
Ensembl
ENSG00000075073
Chromosome
10
Canonical length
398 aa
Protein class
G-protein coupled receptors, Predicted membrane proteins
Subcellular location
Plasma membrane

OverviewNCBI Gene

This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

398 residues, UniProt reviewed canonical sequence.

>P21452|TACR2
     1  MGTCDIVTEA NISSGPESNT TGITAFSMPS WQLALWATAY LALVLVAVTG NAIVIWIILA
    61  HRRMRTVTNY FIVNLALADL CMAAFNAAFN FVYASHNIWY FGRAFCYFQN LFPITAMFVS
   121  IYSMTAIAAD RYMAIVHPFQ PRLSAPSTKA VIAGIWLVAL ALASPQCFYS TVTMDQGATK
   181  CVVAWPEDSG GKTLLLYHLV VIALIYFLPL AVMFVAYSVI GLTLWRRAVP GHQAHGANLR
   241  HLQAMKKFVK TMVLVVLTFA ICWLPYHLYF ILGSFQEDIY CHKFIQQVYL ALFWLAMSST
   301  MYNPIIYCCL NHRFRSGFRL AFRCCPWVTP TKEDKLELTP TTSLSTRVNR CHTKETLFMA
   361  GDTAPSEATS GEAGRPQDGS GLWFGYGLLA PTKTHVEI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TACR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
134 nTPM

Expression across tissuesHPA

Tissue

  • colon: 134 nTPM
  • urinary bladder: 35 nTPM
  • smooth muscle: 31 nTPM
  • stomach: 27 nTPM
  • small intestine: 23 nTPM
  • fallopian tube: 19 nTPM

Single-cell type

  • smooth muscle cells: 44 nCPM
  • tuft cells: 12 nCPM
  • retinal horizontal cells: 10 nCPM
  • cardiomyocytes: 9.7 nCPM
  • epicardial cells: 6.8 nCPM
  • hepatic stellate cells: 6.5 nCPM

Immune cell

  • intermediate monocyte: 1.3 nTPM
  • myeloid DC: 0.6 nTPM
  • non-classical monocyte: 0.6 nTPM
  • classical monocyte: 0.4 nTPM
  • memory B-cell: 0.3 nTPM
  • basophil: 0.2 nTPM

Brain region

  • hippocampal formation: 14 nTPM
  • cerebral cortex: 14 nTPM
  • cerebellum: 14 nTPM
  • amygdala: 13 nTPM
  • basal ganglia: 13 nTPM
  • white matter: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.16
gnomAD pLI
0
gnomAD missense Z
0.43
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TACR2 as an antibody target. Whether an autoantibody or antibody against TACR2 could matter depends on whether native TACR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TACR2 is annotated at the cell surface, where native TACR2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TACR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TACR2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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