Seroatlas · Human Serome Atlas

TAC4

Tachykinin-4

Also known as: HK-1, PPT-C, Pptc, TKN4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86UU9
Gene: TAC4
Ensembl: ENSG00000176358
Chromosome: 17
Canonical length: 113 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene is a member of the tachykinin family of neurotransmitter-encoding genes. Tachykinin proteins are cleaved into small, secreted peptides that activate members of a family of receptor proteins. The products of this gene preferentially activate tachykinin receptor 1, and are thought to regulate peripheral endocrine and paracrine functions including blood pressure, the immune system, and endocrine gland secretion. The products of this gene lack a dibasic cleavage site found in other tachykinin proteins. Consequently, the nature of the cleavage products generated in vivo remains to be determined. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

113 residues, UniProt reviewed canonical sequence.

>Q86UU9|TAC4
     1  MLPCLALLLL MELSVCTVAG DGGEEQTLST EAETWVIVAL EEGAGPSIQL QLQEVKTGKA
    61  SQFFGLMGKR VGGRPLIQPR RKKAYQLEHT FQGLLGKRSL FTEGREDEAQ GSE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAC4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 5.1 nTPM

Expression across tissuesHPA

Tissue

pituitary gland: 5.1 nTPM
choroid plexus: 2.5 nTPM
skin: 1.5 nTPM
liver: 1.3 nTPM
heart muscle: 1 nTPM
bone marrow: 0.6 nTPM

Single-cell type

epicardial cells: 25 nCPM
tuft cells: 23 nCPM
retinal ganglion cells: 19 nCPM
myonuclei: 17 nCPM
retinal bipolar cells: 15 nCPM
podocytes: 13 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 11 nTPM
cerebral cortex: 9.6 nTPM
choroid plexus: 8.9 nTPM
amygdala: 8 nTPM
basal ganglia: 6.9 nTPM
hypothalamus: 6.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.66
gnomAD pLI: 0
gnomAD missense Z: 0.07
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

Tachykinin/Neurokinin-like, conserved site

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TAC4 as an antibody target. Whether an autoantibody or antibody against TAC4 could matter depends on whether native TAC4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TAC4 is annotated as secreted, so native TAC4 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label TAC4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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