Seroatlas · Human Serome Atlas

TAC3

Tachykinin-3

Also known as: LncZBTB39, LncZBTB39-1:2, NK3, NKB, NKNB, TKNK_HUMAN, ZNEUROK1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UHF0
Gene
TAC3
Ensembl
ENSG00000166863
Chromosome
12
Canonical length
121 aa
Protein class
Disease related genes, Human disease related genes, Predicted secreted proteins
Subcellular location
Vesicles
Secretome location
Secreted in female reproductive system

OverviewNCBI Gene

This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded preproprotein is proteolytically processed to generate the mature peptide, which is primarily expressed in the central and peripheral nervous systems and functions as a neurotransmitter. This peptide is the ligand for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with normosmic hypogonadotropic hypogonadism. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

Canonical amino-acid sequenceUniProt

121 residues, UniProt reviewed canonical sequence.

>Q9UHF0|TAC3
     1  MRIMLLFTAI LAFSLAQSFG AVCKEPQEEV VPGGGRSKRD PDLYQLLQRL FKSHSSLEGL
    61  LKALSQASTD PKESTSPEKR DMHDFFVGLM GKRSVQPDSP TDVNQENVPS FGILKYPPRA
   121  E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.64
Highest tissue expression
405 nTPM

Expression across tissuesHPA

Tissue

  • placenta: 405 nTPM
  • hypothalamus: 28 nTPM
  • cerebral cortex: 24 nTPM
  • basal ganglia: 24 nTPM
  • spinal cord: 19 nTPM
  • stomach: 12 nTPM

Single-cell type

  • enterocytes: 107 nCPM
  • brain inhibitory neurons: 28 nCPM
  • extravillous trophoblasts: 23 nCPM
  • syncytiotrophoblasts: 23 nCPM
  • enteric transient amplifying cells: 22 nCPM
  • colonocytes: 20 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • spinal cord: 50 nTPM
  • hypothalamus: 41 nTPM
  • basal ganglia: 21 nTPM
  • medulla oblongata: 14 nTPM
  • cerebral cortex: 13 nTPM
  • white matter: 11 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TAC3.

Disease | AllUniProt

Conditions TAC3 is implicated in, by any mechanism.

  • Hypogonadotropic hypogonadism 10 with or without anosmia (HH10) MIM:614839

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 42 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.19
gnomAD pLI
0.01
gnomAD missense Z
0.69
DepMap mean gene effect
-0.18
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TAC3 as an antibody target. Whether an autoantibody or antibody against TAC3 could matter depends on whether native TAC3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TAC3 is annotated as secreted, so native TAC3 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label TAC3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TAC3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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