Seroatlas · Human Serome Atlas

SZRD1

SUZ RNA-binding domain-containing

Also known as: C1orf144, DKFZp566C0424, SZRD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z422
Gene
SZRD1
Ensembl
ENSG00000055070
Chromosome
1
Canonical length
152 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

No narrative summary is available for SZRD1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

152 residues, UniProt reviewed canonical sequence.

>Q7Z422|SZRD1
     1  MEDEEVAESW EEAADSGEID RRLEKKLKIT QKESRKSKSP PKVPIVIQDD SLPAGPPPQI
    61  RILKRPTSNG VVSSPNSTSR PTLPVKSLAQ REAEYAEARK RILGSASPEE EQEKPILDRP
   121  TRISQPEDSR QPNNVIRQPL GPDGSQGFKQ RR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SZRD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.63
Highest tissue expression
113 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 113 nTPM
  • blood vessel: 79 nTPM
  • bone marrow: 78 nTPM
  • parathyroid gland: 65 nTPM
  • tongue: 64 nTPM
  • esophagus: 64 nTPM

Single-cell type

  • esophageal apical cells: 205 nCPM
  • platelets: 129 nCPM
  • esophageal suprabasal cells: 121 nCPM
  • megakaryocytes: 118 nCPM
  • syncytiotrophoblasts: 112 nCPM
  • extravillous trophoblasts: 107 nCPM

Immune cell

  • non-classical monocyte: 79 nTPM
  • eosinophil: 68 nTPM
  • naive B-cell: 68 nTPM
  • total PBMC: 65 nTPM
  • intermediate monocyte: 65 nTPM
  • memory B-cell: 58 nTPM

Brain region

  • medulla oblongata: 65 nTPM
  • thalamus: 63 nTPM
  • basal ganglia: 54 nTPM
  • midbrain: 52 nTPM
  • spinal cord: 51 nTPM
  • pons: 50 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.67
gnomAD pLI
0.6
gnomAD missense Z
0.52
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SZRD1 as an antibody target. Whether an autoantibody or antibody against SZRD1 could matter depends on whether native SZRD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SZRD1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SZRD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SZRD1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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