Seroatlas · Human Serome Atlas

SYPL2

Synaptophysin-like protein 2

Also known as: Mg29, SYPL2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VXT5
Gene: SYPL2
Ensembl: ENSG00000143028
Chromosome: 1
Canonical length: 272 aa
Protein class: Predicted membrane proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Involved in substantia nigra development. Predicted to be located in membrane and synaptic vesicle. Predicted to be active in synaptic vesicle membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

272 residues, UniProt reviewed canonical sequence.

>Q5VXT5|SYPL2
     1  MSSTESAGRT ADKSPRQQVD RLLVGLRWRR LEEPLGFIKV LQWLFAIFAF GSCGSYSGET
    61  GAMVRCNNEA KDVSSIIVAF GYPFRLHRIQ YEMPLCDEES SSKTMHLMGD FSAPAEFFVT
   121  LGIFSFFYTM AALVIYLRFH NLYTENKRFP LVDFCVTVSF TFFWLVAAAA WGKGLTDVKG
   181  ATRPSSLTAA MSVCHGEEAV CSAGATPSMG LANISVLFGF INFFLWAGNC WFVFKETPWH
   241  GQGQGQDQDQ DQDQGQGPSQ ESAAEQGAVE KQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SYPL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 341 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 341 nTPM
tongue: 164 nTPM
heart muscle: 18 nTPM
adrenal gland: 11 nTPM
kidney: 9 nTPM
liver: 9 nTPM

Single-cell type

myonuclei: 428 nCPM
thymic myoid cells: 61 nCPM
adrenal cortex cells: 48 nCPM
sertoli cells: 46 nCPM
proximal tubule cells: 30 nCPM
loop of henle epithelial cells: 30 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 7.3 nTPM
cerebral cortex: 3.7 nTPM
thalamus: 2.4 nTPM
hippocampal formation: 2.2 nTPM
amygdala: 2.1 nTPM
basal ganglia: 2.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.2
gnomAD pLI: 0
gnomAD missense Z: 0.4
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

synaptic vesicle membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SYPL2 as an antibody target. Whether an autoantibody or antibody against SYPL2 could matter depends on whether native SYPL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SYPL2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SYPL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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