Seroatlas · Human Serome Atlas

SYNPR

Synaptoporin

Also known as: MGC26651, SPO, SYNPR_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TBG9
Gene: SYNPR
Ensembl: ENSG00000163630
Chromosome: 3
Canonical length: 265 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Vesicles,Cytosol

OverviewNCBI Gene

Predicted to be involved in modulation of chemical synaptic transmission. Predicted to be located in membrane; neuron projection; and synaptic vesicle. Predicted to be active in hippocampal mossy fiber to CA3 synapse and synaptic vesicle membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

265 residues, UniProt reviewed canonical sequence.

>Q8TBG9|SYNPR
     1  MCMVIFAPLF AIFAFATCGG YSGGLRLSVD CVNKTESNLS IDIAFAYPFR LHQVTFEVPT
    61  CEGKERQKLA LIGDSSSSAE FFVTVAVFAF LYSLAATVVY IFFQNKYREN NRGPLIDFIV
   121  TVVFSFLWLV GSSAWAKGLS DVKVATDPKE VLLLMSACKQ PSNKCMAIHS PVMSSLNTSV
   181  VFGFLNFILW AGNIWFVFKE TGWHSSGQRY LSDPMEKHSS SYNQGGYNQD SYGSSSGYSQ
   241  QASLGPTSDE FGQQPTGPTS FTNQI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SYNPR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 262 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 262 nTPM
cerebellum: 106 nTPM
cerebral cortex: 58 nTPM
hippocampal formation: 57 nTPM
amygdala: 49 nTPM
hypothalamus: 36 nTPM

Single-cell type

retinal amacrine cells: 872 nCPM
retinal horizontal cells: 831 nCPM
brain inhibitory neurons: 724 nCPM
brain excitatory neurons: 434 nCPM
pituitary stem cells: 191 nCPM
other brain neurons: 126 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 253 nTPM
basal ganglia: 188 nTPM
cerebellum: 103 nTPM
hippocampal formation: 82 nTPM
thalamus: 81 nTPM
white matter: 79 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.88
gnomAD pLI: 0
gnomAD missense Z: 0.42
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SYNPR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

FATE1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SYNPR as an antibody target. Whether an autoantibody or antibody against SYNPR could matter depends on whether native SYNPR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SYNPR is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SYNPR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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